The Function of HTR6
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
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Protein names
Recommended name:
5-hydroxytryptamine receptor 6Short name:
5-HT6Alternative name(s):
5-HT-6Serotonin receptor 6
- RS1805054 (HTR6) ??
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Top Gene-Substance Interactions
HTR6 Interacts with These Diseases
| Disease | Score |
Substances That Increase HTR6
| Substances | Interaction | Organism | Category |
Substances That Decrease HTR6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in several human brain regions, most prominently in the caudate nucleus.
Gene Pathways:
Molecular Function:
- G-Protein Coupled Serotonin Receptor Activity
- Histamine Receptor Activity
- Neurotransmitter Receptor Activity
Biological Processes:
- Cerebral Cortex Cell Migration
- Chemical Synaptic Transmission
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Positive Regulation Of Tor Signaling
Drug Bank:
- Amitriptyline
- Amoxapine
- Asenapine
- Ergoloid Mesylate
- Clozapine
- Doxepin
- Imipramine
- Loxapine
- Mianserin
- Nortriptyline
- Olanzapine
- Sertindole
- Ziprasidone
- Aripiprazole
- Chlorpromazine
- Iloperidone
- Quetiapine