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  3. HTR6

HTR6 (5-hydroxytryptamine receptor 6)

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The Function of HTR6

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).

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Protein names

Recommended name:

5-hydroxytryptamine receptor 6

Short name:

5-HT6

Alternative name(s):

5-HT-6
Serotonin receptor 6

HTR6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1805054 (HTR6) ??

Top Gene-Substance Interactions

HTR6 Interacts with These Diseases

Disease Score

Substances That Increase HTR6

Substances Interaction Organism Category

Substances That Decrease HTR6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB

Tissue specificity:

Expressed in several human brain regions, most prominently in the caudate nucleus.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway

Molecular Function:

  • G-Protein Coupled Serotonin Receptor Activity
  • Histamine Receptor Activity
  • Neurotransmitter Receptor Activity

Biological Processes:

  • Cerebral Cortex Cell Migration
  • Chemical Synaptic Transmission
  • G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
  • Positive Regulation Of Tor Signaling

Drug Bank:

  • Amitriptyline
  • Amoxapine
  • Asenapine
  • Ergoloid Mesylate
  • Clozapine
  • Doxepin
  • Imipramine
  • Loxapine
  • Mianserin
  • Nortriptyline
  • Olanzapine
  • Sertindole
  • Ziprasidone
  • Aripiprazole
  • Chlorpromazine
  • Iloperidone
  • Quetiapine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5-alpha-hydroxytryptamine receptor 6| 5-HT6| 5-HT-6| 5-HT6R| 5-hydroxytryptamine receptor 6 precursor-like protein| 5-hydroxytryptamine (serotonin) receptor 6| 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled| A306_07047| AS27_12935| AS28_08780| D623_10009036| fj36c06| H920_19470| I79_014435| M91_04779| M959_05578| MDA_GLEAN10024274| N300_06007| N301_15786| N302_12221| N303_01367| N305_05183| N306_04731| N307_14926| N312_05094| N321_10010| N322_03202| N324_05770| N327_11924| N328_07479| N330_06345| N331_03126| N332_04154| N333_04969| N334_04666| N335_11831| N340_00667| PAL_GLEAN10015223| PANDA_003707| serotonin receptor 6| ST-B17| Y1Q_005047| Y956_03111| Z169_14464| htr6

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