• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. HTR3B

HTR3B (5-hydroxytryptamine receptor 3B)

Loading...

Summary of HTR3B

5-HT3B are expressed in several brain regions, including the amygdala, caudate, and hippocampus (R).

The 5-HT3R might have a significant role in regulating reward (R).

Genetic variation within HTR3B has been shown to influence vulnerability to bipolar disorder (R) and major depression (R). The 5-HT3 receptor might be a causal factor in alcoholism (R).

0 users want this gene increased, 0 users want it decreased

The Function of HTR3B

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Protein names

Recommended name:

5-hydroxytryptamine receptor 3B

Short name:

5-HT3B

Alternative name(s):

5-HT3-B
Serotonin receptor 3B

HTR3B SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11214775 (HTR3B) ??
  2. RS11606194 (HTR3B) ??
  3. RS1176744 (HTR3B) ??
  4. RS118162387 (HTR3B) ??
  5. RS1672717 (HTR3B) ??
  6. RS2276307 (HTR3B) ??
  7. RS3758987 (HTR3B) ??
  8. RS3782025 (HTR3B) ??
  9. RS7129190 (HTR3B) ??

Top Gene-Substance Interactions

HTR3B Interacts with These Diseases

Disease Score

Substances That Increase HTR3B

Substances Interaction Organism Category

Substances That Decrease HTR3B

Substances Interaction Organism Category

Advanced Summary

Genetic variation within HTR3B has been shown to influence vulnerability to bipolar disorder (R) and major depression (R).

5-HT3B are expressed in several brain regions, including the amygdala, caudate, and hippocampus (R). The 5-HT3R might have a significant role in regulating reward (R).

5-HT3R blockers reduce the number of active dopamine (DA) neurons in the addiction areas of the brain (VTA) (R, R2), whereas local application of a 5-HT3R activators stimulates somatodendritic release of DA (R). 5-HT3R antagonists block both alcohol-stimulated (R) and morphine-stimulated (R) dopamine release in the VTA.

Furthermore, alcohol potentiates the activation of 5-HT3R (R). The 5-HT3 receptor might be a causal factor in alcoholism (R). SNPs in this gene that predispose people to alcoholism and antisocial personality disorders are associated with lowerAlpha (8-13 Hz) EEG waves (R).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Meis-1

Tissue specificity:

Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.

Gene Pathways:

  • Transmembrane transport of small molecules

Molecular Function:

  • Serotonin-Activated Cation-Selective Channel Activity
  • G-Protein Coupled Serotonin Receptor Activity

Biological Processes:

  • Ion Transmembrane Transport

Drug Bank:

  • Ergoloid Mesylate
  • Ethanol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic| 5-HT3B| 5-HT-3B| 5-HT3-B| 5-HT3 receptor subunit B| 5-hydroxytryptamine 3 receptor B subunit| 5-hydroxytryptamine (serotonin) receptor 3B| CB1_000569005| EGK_06912| H920_07557| MDA_GLEAN10018912| PAL_GLEAN10009093| PANDA_018398| serotonin-gated ion channel subunit| serotonin receptor 3B| TREES_T100013258| truncated 5-hydroxytryptamine receptor 3B| htr3b

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved