Summary of HTR3B
5-HT3B are expressed in several brain regions, including the amygdala, caudate, and hippocampus (R).
The 5-HT3R might have a significant role in regulating reward (R).
Genetic variation within HTR3B has been shown to influence vulnerability to bipolar disorder (R) and major depression (R). The 5-HT3 receptor might be a causal factor in alcoholism (R).
The Function of HTR3B
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Protein names
Recommended name:
5-hydroxytryptamine receptor 3BShort name:
5-HT3BAlternative name(s):
5-HT3-BSerotonin receptor 3B
- RS11214775 (HTR3B) ??
- RS11606194 (HTR3B) ??
- RS1176744 (HTR3B) ??
- RS118162387 (HTR3B) ??
- RS1672717 (HTR3B) ??
- RS2276307 (HTR3B) ??
- RS3758987 (HTR3B) ??
- RS3782025 (HTR3B) ??
- RS7129190 (HTR3B) ??
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Top Gene-Substance Interactions
HTR3B Interacts with These Diseases
| Disease | Score |
Substances That Increase HTR3B
| Substances | Interaction | Organism | Category |
Substances That Decrease HTR3B
| Substances | Interaction | Organism | Category |
Advanced Summary
Genetic variation within HTR3B has been shown to influence vulnerability to bipolar disorder (R) and major depression (R).
5-HT3B are expressed in several brain regions, including the amygdala, caudate, and hippocampus (R). The 5-HT3R might have a significant role in regulating reward (R).
5-HT3R blockers reduce the number of active dopamine (DA) neurons in the addiction areas of the brain (VTA) (R, R2), whereas local application of a 5-HT3R activators stimulates somatodendritic release of DA (R). 5-HT3R antagonists block both alcohol-stimulated (R) and morphine-stimulated (R) dopamine release in the VTA.
Furthermore, alcohol potentiates the activation of 5-HT3R (R). The 5-HT3 receptor might be a causal factor in alcoholism (R). SNPs in this gene that predispose people to alcoholism and antisocial personality disorders are associated with lowerAlpha (8-13 Hz) EEG waves (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
Gene Pathways:
Molecular Function:
Biological Processes:
Drug Bank:
- Ergoloid Mesylate
- Ethanol