Summary of HTR2C

HTR2C encodes a protein receptor. It can be modified by RNA editing, which can cause problems (R). 

Abnormalities caused by RNA editing can cause depression, and other naturally occurring changes in this gene can cause mental disorders (R). 

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The Function of HTR2C

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Protein names

Recommended name:

5-hydroxytryptamine receptor 2C

Short name:

5-HT2C

Alternative name(s):

5-HT-2C
5-HTR2C
5-hydroxytryptamine receptor 1C
5-HT-1C
5-HT1C
Serotonin receptor 2C

Top Gene-Substance Interactions

HTR2C Interacts with These Diseases

Substances That Increase HTR2C

Substances That Decrease HTR2C

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical