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  3. HTR2C

HTR2C (5-hydroxytryptamine receptor 2C)

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Summary of HTR2C

HTR2C encodes a protein receptor. It can be modified by RNA editing, which can cause problems (R). 

Abnormalities caused by RNA editing can cause depression, and other naturally occurring changes in this gene can cause mental disorders (R). 

0 users want this gene increased, 0 users want it decreased

The Function of HTR2C

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Protein names

Recommended name:

5-hydroxytryptamine receptor 2C

Short name:

5-HT2C

Alternative name(s):

5-HT-2C
5-HTR2C
5-hydroxytryptamine receptor 1C
5-HT-1C
5-HT1C
Serotonin receptor 2C

HTR2C SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1414334 (HTR2C) ??
  2. RS3813928 (HTR2C) ??
  3. RS3813929 (HTR2C) ??
  4. RS498207 (HTR2C) ??
  5. RS518147 (HTR2C) ??
  6. RS521018 (HTR2C) ??
  7. RS6318 (HTR2C) ??

Top Gene-Substance Interactions

HTR2C Interacts with These Diseases

Disease Score

Substances That Increase HTR2C

Substances Interaction Organism Category

Substances That Decrease HTR2C

Substances Interaction Organism Category

Advanced Summary

HTR2C encodes a protein receptor. It can be modified by RNA editing, which can cause problems (R). 

Abnormalities caused by RNA editing can cause depression, and other naturally occurring changes in this gene can cause mental disorders (R). 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1

Tissue specificity:

Detected in brain.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway

Molecular Function:

  • 1-(4-Iodo-2,5-Dimethoxyphenyl)Propan-2-Amine Binding
  • Drug Binding
  • G-Protein Coupled Serotonin Receptor Activity
  • Gq/11-Coupled Serotonin Receptor Activity
  • Neurotransmitter Receptor Activity
  • Serotonin Binding

Biological Processes:

  • Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
  • Behavioral Fear Response
  • Cellular Calcium Ion Homeostasis
  • Cgmp Biosynthetic Process
  • Chemical Synaptic Transmission
  • Feeding Behavior
  • Locomotory Behavior
  • Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Phospholipase C-Activating Serotonin Receptor Signaling Pathway
  • Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-Activating G-Protein Coupled Signaling Pathway
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Fat Cell Differentiation
  • Positive Regulation Of Phosphatidylinositol Biosynthetic Process
  • Regulation Of Appetite
  • Regulation Of Corticotropin-Releasing Hormone Secretion
  • Regulation Of Neurological System Process
  • Release Of Sequestered Calcium Ion Into Cytosol
  • Serotonin Receptor Signaling Pathway

Drug Bank:

  • Agomelatine
  • Captodiame
  • Ergoloid Mesylate
  • Paliperidone
  • Amoxapine
  • Aripiprazole
  • Asenapine
  • Bromocriptine
  • Cabergoline
  • Chlorpromazine
  • Chlorprothixene
  • Clozapine
  • Cyproheptadine
  • Desipramine
  • Dexfenfluramine
  • Doxepin
  • Ergotamine
  • Imipramine
  • Lisuride
  • Lorcaserin
  • Loxapine
  • Maprotiline
  • Methysergide
  • Mianserin
  • Minaprine
  • Mirtazapine
  • Nefazodone
  • Olanzapine
  • Pergolide
  • Pramipexole
  • Promazine
  • Propiomazine
  • Quetiapine
  • Ropinirole
  • Sertindole
  • Tramadol
  • Trazodone
  • Yohimbine
  • Ziprasidone
  • Amitriptyline
  • Apomorphine
  • Clomipramine
  • Ketamine
  • Methotrimeprazine
  • Nortriptyline
  • Risperidone
  • Trimipramine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5-alpha-hydroxytryptamine receptor 2C| 5HT1c| 5-HT1C| 5-HT-1C| 5HT-1C| 5HT2C| 5-HT2C| 5-HT-2C| 5-HT2cR| 5-HT2C receptor| 5HTR2C| 5-HTR2C| 5-hydroxytryptamine receptor 1C| 5-hydroxytryptamine receptor 2B| 5-hydroxytryptamine (serotonin) receptor 2C| 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled| AS27_07273| AS28_14185| CB1_002665001| D623_10018277| EGK_20841| GW7_17975| H920_14546| Htr1c| I79_016842| M959_07942| N300_15183| N301_11254| N302_09364| N305_03735| N306_08691| N307_00561| N308_01387| N309_11894| N310_13231| N312_04520| N320_02386| N321_13517| N322_04221| N325_12878| N326_07811| N327_00784| N328_07057| N329_09423| N332_10176| N333_08289| N334_06042| N335_04478| N336_07566| N339_02931| N340_09960| N341_01263| PAL_GLEAN10004446| PANDA_013899| serotonin 1c receptor| serotonin 5-HT-1C receptor| serotonin 5-HT-2C receptor| serotonin receptor 2C| SR1| TREES_T100009490| UY3_03554| Y1Q_016966| Y956_03638| Z169_09917| htr2c

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