Summary of HTR2C
The Function of HTR2C
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Protein names
Recommended name:
5-hydroxytryptamine receptor 2CShort name:
5-HT2CAlternative name(s):
5-HT-2C5-HTR2C
5-hydroxytryptamine receptor 1C
5-HT-1C
5-HT1C
Serotonin receptor 2C
- RS1414334 (HTR2C) ??
- RS3813928 (HTR2C) ??
- RS3813929 (HTR2C) ??
- RS498207 (HTR2C) ??
- RS518147 (HTR2C) ??
- RS521018 (HTR2C) ??
- RS6318 (HTR2C) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
HTR2C Interacts with These Diseases
Disease | Score |
Substances That Increase HTR2C
Substances | Interaction | Organism | Category |
Substances That Decrease HTR2C
Substances | Interaction | Organism | Category |
Advanced Summary
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in brain.
Gene Pathways:
Molecular Function:
- 1-(4-Iodo-2,5-Dimethoxyphenyl)Propan-2-Amine Binding
- Drug Binding
- G-Protein Coupled Serotonin Receptor Activity
- Gq/11-Coupled Serotonin Receptor Activity
- Neurotransmitter Receptor Activity
- Serotonin Binding
Biological Processes:
- Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
- Behavioral Fear Response
- Cellular Calcium Ion Homeostasis
- Cgmp Biosynthetic Process
- Chemical Synaptic Transmission
- Feeding Behavior
- Locomotory Behavior
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Phospholipase C-Activating Serotonin Receptor Signaling Pathway
- Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-Activating G-Protein Coupled Signaling Pathway
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Fat Cell Differentiation
- Positive Regulation Of Phosphatidylinositol Biosynthetic Process
- Regulation Of Appetite
- Regulation Of Corticotropin-Releasing Hormone Secretion
- Regulation Of Neurological System Process
- Release Of Sequestered Calcium Ion Into Cytosol
- Serotonin Receptor Signaling Pathway
Drug Bank:
- Agomelatine
- Captodiame
- Ergoloid Mesylate
- Paliperidone
- Amoxapine
- Aripiprazole
- Asenapine
- Bromocriptine
- Cabergoline
- Chlorpromazine
- Chlorprothixene
- Clozapine
- Cyproheptadine
- Desipramine
- Dexfenfluramine
- Doxepin
- Ergotamine
- Imipramine
- Lisuride
- Lorcaserin
- Loxapine
- Maprotiline
- Methysergide
- Mianserin
- Minaprine
- Mirtazapine
- Nefazodone
- Olanzapine
- Pergolide
- Pramipexole
- Promazine
- Propiomazine
- Quetiapine
- Ropinirole
- Sertindole
- Tramadol
- Trazodone
- Yohimbine
- Ziprasidone
- Amitriptyline
- Apomorphine
- Clomipramine
- Ketamine
- Methotrimeprazine
- Nortriptyline
- Risperidone
- Trimipramine