Summary of HTR1A

The HTR1A gene codes for 5-hydroxytryptamine receptor 1A (5-HT1A). 5-HT1A is a receptor for the chemical messenger serotonin [R, R].

Certain medications for schizophrenia and related conditions function by binding to 5-HT1A and increasing its activity [R, R].

HTR1A variants have been linked to [R, R, R, R]:

Fear and anxiety
Efficacy of medications for schizophrenia and related conditions

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Protein names

Recommended name:

5-hydroxytryptamine receptor 1A

Short name:

G-21

Alternative name(s):

5-HT-1A
5-HT1A
Serotonin receptor 1A

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RS10042486 (HTR1A) ??
RS1364043 (HTR1A) ??
RS1494630 (HTR1A) ??
RS6295 (HTR1A) ??

Top Gene-Substance Interactions

HTR1A Interacts with These Diseases

Disease	Score

Fixes

How to Naturally Modulate 5HT1A Receptors

Melatonin potentiates the 5-HT1A receptor in the hypothalamus, which results in its cooling effects (R).

T3 is effective in both augmenting and accelerating the therapeutic response to antidepressant drugs. When given to animals, it reduced the sensitivity of 5-HT1A (and 5HT1B) auto-receptors (and postsynaptic) in the hypothalamus (R). I do notice an anti-depressant effect when I up my thyroid hormone production with ICES/LLLT.

Estradiol accelerates the effects of fluoxetine (SSRI) on these receptors, presumably by blunting the increase in 5HT1A autoreceptors from SSRIs in the hypothalamus (PVN) (R).

Exercise (aerobic) increases 5HT1A receptors in the dorsal raphe when they were reduced in an animal stress model (R).

DHA prevented negative effects of a high-fat diet on the 5-HT1A receptor (R).

Omega 3’s/Fish Oil …When animals were fed diets low in Omega-3’s (ALA), 5-HT1A receptors decreased, causing the SSRI not to work properly (R).

Magnesium and Calcium (divalent cations) increase the binding of serotonin to the 5HT1A receptors in the cortex (Purkinje cells) (R). Manganese also helps 5HT1A activators bind better. (R),

Lithium increases 5HT1A postsynaptic sensitivity, while not changing the autoreceptors and it’s thought that this is in part responsible for its anti-depressant activity (R).

Zinc acts as a blocker of the 5HT1A receptor and prevents the binding of this receptor (R). However, it also helps block the combining of the 5HT1A receptor and another receptor (galanin 1), which results in an anti-depressive effect (R).

Butyrate increases 5-HT1A receptors in the hypothalamus, which should result in a similar effect. (R)

St John’s Wort increases the number of postsynaptic 5-HT_1A (and 5-HT_2A) receptors (R).

Rhodiola increases the number of 5HT1A receptors (R).

Ashwagandha decreases 5-HT1A signaling (R).

Fixes Advanced

Other Ways to Modulate 5HT1A Receptors

Curcumin (R),
Ginger is a partial activator of 5HT1A (R),
Bitter orange essential oil (R),
CBD (partial) (R, R2),
Kudzu root/Puerarin (R),
Hesperidin (R)
Yohimbine (R)
Ginkgo (R)

Drugs:

Buspirone (R),
Shrooms/Psilocybin (R),
MDMA or the pure version of ecstasy increases feelings of love, empathy, and connection to others by stimulating oxytocin activity primarily via activation of the 5-HT1A receptors (R).
Quetiapine (R),
Amphetamines (R),
LSD (R).

Chronic intake of SSRIs induces less sensitivity of the auto- and post-synaptic 5-HT1Areceptors in the hypothalamus, so it’s both good and bad, but better than not for some people (R).

Chronic exposure to cortisol desensitizes 5-HT1A autoreceptors receptors (R).

Chronic Transcranial Magnetic Stimulation (rTMS) reduces the sensitivity of post-synaptic 5-HT1A receptors in the hypothalamus, and the study says that “this may be significant in relation to the therapeutic mechanism of rTMS.” (R)

Berberine decreases the serotonergic system by activation of 5-HT1A autoreceptors and inhibition of postsynaptic 5-HT1A and 5-HT2 receptors. Since serotonin is mainly an excitatory neurotransmitter, this effect decreased anxiety in animals (R).

Substances That Increase HTR1A

Category:

Substances	Interaction	Organism	Category

Substances That Decrease HTR1A

Category:

Substances	Interaction	Organism	Category

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.

Gene Pathways:

Molecular Function:

Biological Processes:

Drug Bank:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5ht1a| 5-HT1A| 5-HT-1A| 5-HT1A receptor| 5htr1a| 5-hydroxytryptamine receptor 1A-alpha| 5-hydroxytryptamine receptor 1A-beta| 5-hydroxytryptamine (serotonin) receptor 1A| 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled| adrb2rl1| adrbrl1| AS27_15492| AS28_11480| CB1_000872011| EGK_16528| EH28_11273| G-21| Gpcr18| G-protein coupled receptor 18| guanine nucleotide-binding regulatory protein-coupled receptor| GW7_05879| H920_10840| htr1a-B| N300_04289| N302_08541| N303_02520| N305_12338| N306_15569| N307_07489| N311_06702| N325_03832| PANDA_015985| PFMCD| RAT5HT1A| serotonin 1A receptor| serotonin 5-HT1A receptor| serotonin receptor 1A| serotonin receptor type 1A| UY3_02797| Y1Q_009548| Y956_04870| htr1a

HTR1A (5-hydroxytryptamine receptor 1A)

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