Summary of HTATIP2
The gene codes for a protein, HIV-1 Tat interactive protein 2. It is on chromosome 11 [R].
The Function of HTATIP2
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Protein names
Recommended name:
Oxidoreductase HTATIP2Alternative name(s):
30 kDa HIV-1 TAT-interacting proteinHIV-1 TAT-interactive protein 2
- RS11025523 (HTATIP2) ??
- RS1353649 (HTATIP2) ??
- RS1520896 (HTATIP2) ??
- RS3824886 (HTATIP2) ??
- RS7128099 (HTATIP2) ??
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Top Gene-Substance Interactions
Substances That Increase HTATIP2
| Substances | Interaction | Organism | Category |
Substances That Decrease HTATIP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.
Caution:
Was originally (PubMed:9482853 and PubMed:10698937) thought to be a transcriptional coregulator with protein kinase activity. However, crystal structure reveals a short chain dehydrogenase/reductase fold binding NADPH rather than ATP.
Molecular Function:
Biological Processes:
- Angiogenesis
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Apoptotic Process
- Viral Process
- Cell Differentiation
- Negative Regulation Of Apoptotic Process
- Regulation Of Angiogenesis
- Nuclear Import