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HTATIP2 (HIV-1 Tat interactive protein 2)

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Summary of HTATIP2

The gene codes for a protein, HIV-1 Tat interactive protein 2. It is on chromosome 11 [R].

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The Function of HTATIP2

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Protein names

Recommended name:

Oxidoreductase HTATIP2

Alternative name(s):

30 kDa HIV-1 TAT-interacting protein
HIV-1 TAT-interactive protein 2

HTATIP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11025523 (HTATIP2) ??
  2. RS1353649 (HTATIP2) ??
  3. RS1520896 (HTATIP2) ??
  4. RS3824886 (HTATIP2) ??
  5. RS7128099 (HTATIP2) ??

Top Gene-Substance Interactions

Substances That Increase HTATIP2

Substances Interaction Organism Category

Substances That Decrease HTATIP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • RORalpha1
  • AP-1
  • c-Jun
  • c-Fos
  • NF-E2
  • NF-E2 p45
  • Fra-1
  • JunD

Tissue specificity:

Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.

Caution:

Was originally (PubMed:9482853 and PubMed:10698937) thought to be a transcriptional coregulator with protein kinase activity. However, crystal structure reveals a short chain dehydrogenase/reductase fold binding NADPH rather than ATP.

Molecular Function:

  • Oxidoreductase Activity
  • Transcription Coactivator Activity

Biological Processes:

  • Angiogenesis
  • Apoptotic Process
  • Cell Differentiation
  • Negative Regulation Of Apoptotic Process
  • Nuclear Import
  • Regulation Of Angiogenesis
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Viral Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 30 kDa HIV-1 TAT-interacting protein| AS27_00355| AS28_09887| Cc3| D623_10018676| fb15b04| HIV-1 TAT-interactive protein 2| HIV-1 Tat interactive protein 2, 30kDa| HIV-1 tat interactive protein 2, 30 kDa homolog| HIV-1 tat interactive protein 2, homolog| htai2| M91_05365| M959_05850| MDA_GLEAN10023849| N300_02692| N301_09618| N302_00558| N303_03598| N305_11287| N306_01439| N307_11703| N308_05742| N309_13912| N312_08183| N320_04551| N321_06030| N322_05929| N324_09242| N325_09657| N326_05071| N330_04382| N331_09621| N332_00866| N333_06119| N334_01189| N335_00177| N339_11812| oxidoreductase HTATIP2| oxidoreductase HTATIP2-like| PAL_GLEAN10017984| PANDA_008834| SDR44U1| short chain dehydrogenase/reductase family 44U, member 1| Tat-interacting protein (30kD)| tat-interacting protein 30 kDa| tip30| TREES_T100000375| Y1Q_029555| Y956_03492| Z169_13505| htatip2

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