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  3. HSPH1

HSPH1 (Heat shock protein family H (Hsp110) member 1)

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The Function of HSPH1

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.

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Protein names

Recommended name:

Heat shock protein 105 kDa

Alternative name(s):

Antigen NY-CO-25
Heat shock 110 kDa protein

HSPH1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS912294 (HSPH1) ??

Top Gene-Substance Interactions

HSPH1 Interacts with These Diseases

Disease Score

Substances That Increase HSPH1

Substances Interaction Organism Category

Substances That Decrease HSPH1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • E4BP4
  • Msx-1
  • USF1
  • USF-1

Tissue specificity:

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.

Gene Pathways:

  • Protein processing in endoplasmic reticulum

Molecular Function:

  • Adenyl-Nucleotide Exchange Factor Activity
  • Atp Binding

Biological Processes:

  • Chaperone Mediated Protein Folding Requiring Cofactor
  • Negative Regulation Of Establishment Of Protein Localization To Mitochondrion
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
  • Negative Regulation Of P38mapk Cascade
  • Positive Regulation Of Mhc Class I Biosynthetic Process
  • Positive Regulation Of Nk T Cell Activation
  • Positive Regulation Of Protein Tyrosine Kinase Activity
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Receptor-Mediated Endocytosis
  • Regulation Of Cellular Response To Heat
  • Response To Unfolded Protein
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| heat shock protein| 105kDa| 42 degrees C-HSP| Anapl_06914| antigen NY-CO-25| AS27_03116| AS28_02382| CB1_001253002| D623_10026464| GW7_02038| H920_05252| heat shock 105/110 protein 1| heat shock 105kD| heat shock 105kDa| heat shock 105kDa/110kDa protein 1| heat shock 105kD alpha| heat shock 105kD beta| Heat shock 110 kDa protein| heat shock protein 105| Heat shock protein 105 kDa| Heat shock protein 105 kDa-like protein| heat shock protein 110| heat-shock protein 110 kDa| heat shock-related 100 kDa protein E7I| hsp105| HSP105 42 C-HSP| HSP105A| HSP105B| hsp110| hsp110/105| hsp-E7I| hsph1-a| hsph1-b| I79_002075| M91_03491| M959_06290| N301_16579| N302_00892| N303_02121| N305_12002| N306_02341| N307_02358| N308_01832| N309_01449| N310_10917| N311_01855| N312_07106| N320_03792| N322_12336| N324_02591| N326_07173| N328_12722| N331_06327| N332_13224| N333_01568| N334_11256| N335_09240| N336_04631| N339_11633| N340_14909| N341_01014| NY-CO-25| PAL_GLEAN10006794| PANDA_002725| TREES_T100014349| UY3_00132| Y1Q_027286| Y956_13453| Z169_09831| hsph1

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