The Function of HSPH1
Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
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Protein names
Recommended name:
Heat shock protein 105 kDaAlternative name(s):
Antigen NY-CO-25Heat shock 110 kDa protein
- RS912294 (HSPH1) ??
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Top Gene-Substance Interactions
HSPH1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSPH1
| Substances | Interaction | Organism | Category |
Substances That Decrease HSPH1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
Gene Pathways:
Molecular Function:
Biological Processes:
- Receptor-Mediated Endocytosis
- Response To Unfolded Protein
- Positive Regulation Of Mhc Class I Biosynthetic Process
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Chaperone Mediated Protein Folding Requiring Cofactor
- Positive Regulation Of Nk T Cell Activation
- Positive Regulation Of Protein Tyrosine Kinase Activity
- Regulation Of Cellular Response To Heat
- Negative Regulation Of Establishment Of Protein Localization To Mitochondrion
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
- Negative Regulation Of P38mapk Cascade