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  3. HSPA5

HSPA5 (Heat shock protein family A (Hsp70) member 5)

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Summary of HSPA5

The gene codes for a protein, heat shock protein family A (Hsp70) member 5. It plays a role in monitoring protein transport through the cell [R].

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The Function of HSPA5

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Protein names

Recommended name:

78 kDa glucose-regulated protein

Alternative name(s):

GRP-78
Endoplasmic reticulum lumenal Ca(2+
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein
BiP

HSPA5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS391957 (HSPA5) ??
  2. RS430397 (HSPA5) ??

Top Gene-Substance Interactions

HSPA5 Interacts with These Diseases

Disease Score

Substances That Increase HSPA5

Substances Interaction Organism Category

Substances That Decrease HSPA5

Substances Interaction Organism Category

Advanced Summary

     From UniProt: Autoantigen in rheumatoid arthritis.

     From NCBI Gene: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010] From UniProt: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • deltaCREB
  • NF-kappaB1
  • XBP-1
  • YY1
  • c-Myb
  • p300
  • ATF6

Gene Pathways:

  • Immune System
  • Metabolism of proteins
  • Hemostasis
  • Antigen processing and presentation
  • Prion diseases
  • Protein processing in endoplasmic reticulum
  • Protein export

Molecular Function:

  • Atpase Activity
  • Atp Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Calcium Ion Binding
  • Chaperone Binding
  • Enzyme Binding
  • Glycoprotein Binding
  • Misfolded Protein Binding
  • Protein Domain Specific Binding
  • Ribosome Binding
  • Ubiquitin Protein Ligase Binding
  • Unfolded Protein Binding

Biological Processes:

  • Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
  • Atf6-Mediated Unfolded Protein Response
  • Cellular Response To Antibiotic
  • Cellular Response To Glucose Starvation
  • Cellular Response To Interleukin-4
  • Cellular Response To Manganese Ion
  • Cerebellar Purkinje Cell Layer Development
  • Cerebellum Structural Organization
  • Endoplasmic Reticulum Unfolded Protein Response
  • Er-Associated Ubiquitin-Dependent Protein Catabolic Process
  • Er Overload Response
  • Ire1-Mediated Unfolded Protein Response
  • Maintenance Of Protein Localization In Endoplasmic Reticulum
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Protein Homodimerization Activity
  • Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Perk-Mediated Unfolded Protein Response
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Protein Ubiquitination
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Endoplasmic Reticulum Stress
  • Protein Folding In Endoplasmic Reticulum
  • Regulation Of Atf6-Mediated Unfolded Protein Response
  • Regulation Of Ire1-Mediated Unfolded Protein Response
  • Regulation Of Perk-Mediated Unfolded Protein Response
  • Regulation Of Protein Folding In Endoplasmic Reticulum
  • Substantia Nigra Development
  • Toxin Transport

Drug Bank:

  • Acetylsalicylic Acid
  • Antihemophilic Factor (Recombinant)
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| glucose-regulated protein| 78 kDa glucose-regulated protein| 78 kDa glucose-regulated protein-like protein| 78 kDa glucose regulated protein precursor-like protein| AL022860| AS27_13679| baffled| binding protein| bip| BiP/Grp78| BiP protein| CB1_001026009| D2Wsu141e| D2Wsu17e| endoplasmic reticulum lumenal Ca(2+)-binding protein grp78| epididymis secretory sperm binding protein Li 89n| fb60h09| fi36d04| glucose-regulated protein 78| glucose regulated protein, 78 kDa| glucose-regulated protein, 78kDa| grp78| GRP 78| GRP-78| GW7_01136| heat-shock 70-kDa protein 5| Heat shock 70 kDa protein 5| heat shock 70 kDa protein 5a| heat shock 70kDa protein 5 (glucose-regulated protein)| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)| heat shock 70kD protein 5| heat shock 70kD protein 5 (glucose-regulated protein, 78kD)| heat shock protein 5| heat shock protein 70kDa| heat shock protein family A member 5| heavy-chain binding protein BiP| HEL-S-89n| Hsce70| hspa5a| immunoglobulin binding protein| Immunoglobulin heavy chain-binding protein| M959_09289| mBiP| MDA_GLEAN10019350| MIF2| N300_09344| N301_12531| N302_13016| N303_06254| N305_12567| N306_14463| N307_04904| N308_14213| N309_06058| N310_10987| N312_03834| N320_07897| N321_11125| N322_06847| N326_06248| N327_00451| N328_08890| N329_00106| N331_09325| N332_07525| N333_00278| N334_11476| N335_05260| N336_11484| N339_08006| N340_07701| N341_10623| PAL_GLEAN10012429| PANDA_004422| Sez7| SEZ-7| steroidogenesis-activator polypeptide| TREES_T100009358| UY3_08156| XAP-1| XAP-1 antigen| XELAEV_180384511mg| Y1Q_029469| Y956_02195| Z169_08375| hspa5

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