The Function of HSP90B1
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
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Protein names
Recommended name:
EndoplasminShort name:
GRP-94Alternative name(s):
94 kDa glucose-regulated proteinHeat shock protein 90 kDa beta member 1
Tumor rejection antigen 1
gp96 homolog
Top Gene-Substance Interactions
HSP90B1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSP90B1
| Substances | Interaction | Organism | Category |
Substances That Decrease HSP90B1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Rna Binding
- Calcium Ion Binding
- Atp Binding
- Protein Phosphatase Binding
- Virion Binding
- Low-Density Lipoprotein Particle Receptor Binding
Biological Processes:
- Response To Hypoxia
- Toll-Like Receptor Signaling Pathway
- Receptor-Mediated Endocytosis
- Protein Transport
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Retrograde Protein Transport, Er To Cytosol
- Actin Rod Assembly
- Protein Folding In Endoplasmic Reticulum
- Response To Endoplasmic Reticulum Stress
- Atf6-Mediated Unfolded Protein Response
- Negative Regulation Of Apoptotic Process
- Regulation Of Phosphoprotein Phosphatase Activity
- Sequestering Of Calcium Ion
- Cellular Response To Atp