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HSP90B1 (Heat shock protein 90 beta family member 1)

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The Function of HSP90B1

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

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Protein names

Recommended name:

Endoplasmin

Short name:

GRP-94

Alternative name(s):

94 kDa glucose-regulated protein
Heat shock protein 90 kDa beta member 1
Tumor rejection antigen 1
gp96 homolog

Top Gene-Substance Interactions

HSP90B1 Interacts with These Diseases

Disease Score

Substances That Increase HSP90B1

Substances Interaction Organism Category

Substances That Decrease HSP90B1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • TBP
  • TFIID
  • STAT1beta
  • STAT1alpha
  • STAT1
  • C/EBPbeta
  • c-Myb

Gene Pathways:

  • Immune System
  • Prostate cancer
  • Pathways in cancer
  • NOD-like receptor signaling pathway
  • Protein processing in endoplasmic reticulum
  • Metabolism of proteins

Molecular Function:

  • Rna Binding
  • Calcium Ion Binding
  • Atp Binding
  • Protein Phosphatase Binding
  • Virion Binding
  • Low-Density Lipoprotein Particle Receptor Binding

Biological Processes:

  • Response To Hypoxia
  • Toll-Like Receptor Signaling Pathway
  • Receptor-Mediated Endocytosis
  • Protein Transport
  • Er-Associated Ubiquitin-Dependent Protein Catabolic Process
  • Retrograde Protein Transport, Er To Cytosol
  • Actin Rod Assembly
  • Protein Folding In Endoplasmic Reticulum
  • Response To Endoplasmic Reticulum Stress
  • Atf6-Mediated Unfolded Protein Response
  • Negative Regulation Of Apoptotic Process
  • Regulation Of Phosphoprotein Phosphatase Activity
  • Sequestering Of Calcium Ion
  • Cellular Response To Atp

Drug Bank:

  • Rifabutin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ECGP| 108K heat shock protein| 108K HSP| 94 kDa glucose-regulated protein| 98 kDa protein kinase| A306_12092| Anapl_14998| AS27_12512| AS28_09174| CB1_002313009| D623_10003613| endoplasmic reticulum resident protein 99| endoplasmin| endoplasmin-like protein| endoplasmin precursor-like protein| endothelial cell (HBMEC) glycoprotein| epididymis luminal protein 35| epididymis secretory sperm binding protein Li 125m| ERp99| fb61d09| glucose-regulated protein| glucose-regulated protein GRP94| Gp96| gp96 homolog| grp94| GRP-94| heat shock 108 kDa protein| heat shock protein 108| heat shock protein 90, beta (grp94), member 1| heat shock protein 90, beta, member 1| heat shock protein 90kDa beta family member 1| heat shock protein 90kDa beta (grp94), member 1| heat shock protein 90kDa beta, member 1| Heat shock protein 90 kDa beta member 1| HEL35| HEL-S-125m| hsp108| HSP 108| HSP90 beta| M91_11828| M959_14047| N300_08640| N301_04603| N302_12623| N303_09345| N305_09344| N306_11385| N307_13921| N308_00468| N309_12757| N311_11846| N312_05648| N320_04172| N321_01939| N322_04312| N324_08769| N325_11387| N326_10885| N327_06573| N328_07221| N329_06645| N331_08949| N332_12228| N333_00707| N334_04190| N335_03459| N340_10772| PANDA_003512| polymorphic tumor rejection antigen 1| ppk98| PPK 98| stress-inducible tumor rejection antigen gp96| TA-3| Targ2| tra-1| TRA1| transferrin-binding protein| transforming growth factor alpha regulated gene 2| TREES_T100002542| tumor rejection antigen| tumor rejection antigen 1| tumor rejection antigen gp96| tumor rejection antigen (gp96) 1| Y1Q_025118| Y956_15185| Z169_02794| hsp90b1

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