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  3. HSP90AA1

HSP90AA1 (Heat shock protein 90 alpha family class A member 1)

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The Function of HSP90AA1

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

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Protein names

Recommended name:

Heat shock protein HSP 90-alpha

Short name:

HSP86

Alternative name(s):

Heat shock 86 kDa
HSP 86
Lipopolysaccharide-associated protein 2
LAP-2
LPS-associated protein 2
Renal carcinoma antigen NY-REN-38

HSP90AA1 SNPs

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  1. RS1190596 (HSP90AA1) ??

Top Gene-Substance Interactions

HSP90AA1 Interacts with These Diseases

Disease Score

Substances That Increase HSP90AA1

Substances Interaction Organism Category

Substances That Decrease HSP90AA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • Arnt
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • HSF2

Gene Pathways:

  • Metabolism
  • Disease
  • Immune System
  • Pathways in cancer
  • Signal Transduction
  • Cellular responses to stress
  • Prostate cancer
  • NOD-like receptor signaling pathway
  • Antigen processing and presentation
  • Progesterone-mediated oocyte maturation
  • Protein processing in endoplasmic reticulum

Molecular Function:

  • Atpase Activity
  • Atp Binding
  • Ctp Binding
  • Datp Binding
  • Glycoprotein Binding
  • Gtpase Binding
  • Gtp Binding
  • Histone Deacetylase Binding
  • Identical Protein Binding
  • Mhc Class Ii Protein Complex Binding
  • Mrna Binding
  • Nitric-Oxide Synthase Regulator Activity
  • Nucleotide Binding
  • Poly(A) Rna Binding
  • Protein Homodimerization Activity
  • Protein Tyrosine Kinase Activity
  • Tpr Domain Binding
  • Utp Binding

Biological Processes:

  • Cardiac Muscle Cell Apoptotic Process
  • Chaperone-Mediated Autophagy
  • Chaperone-Mediated Protein Complex Assembly
  • Erbb2 Signaling Pathway
  • Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
  • G2/M Transition Of Mitotic Cell Cycle
  • Mitochondrial Transport
  • Neuron Migration
  • Positive Regulation Of Cardiac Muscle Contraction
  • Positive Regulation Of Cell Size
  • Positive Regulation Of Lamellipodium Assembly
  • Positive Regulation Of Nitric Oxide Biosynthetic Process
  • Positive Regulation Of Protein Import Into Nucleus, Translocation
  • Protein Import Into Mitochondrial Outer Membrane
  • Protein Refolding
  • Protein Stabilization
  • Protein Unfolding
  • Receptor-Mediated Endocytosis
  • Regulation Of Cellular Response To Heat
  • Regulation Of Nitric-Oxide Synthase Activity
  • Regulation Of Protein Ubiquitination
  • Response To Antibiotic
  • Response To Cocaine
  • Response To Cold
  • Response To Estrogen
  • Response To Heat
  • Response To Salt Stress
  • Response To Unfolded Protein
  • Signal Transduction
  • Skeletal Muscle Contraction
  • Vascular Endothelial Growth Factor Receptor Signaling Pathway

Drug Bank:

  • Rifabutin
  • Nedocromil
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 86kDa| 89kDa| 90-kDa heat shock protein| AL024080| AL024147| AS27_04619| AS28_02141| CB1_000223030| D623_10025294| EL52| epididymis luminal secretory protein 52| epididymis secretory sperm binding protein Li 65p| H920_16300| heat shock 86 kDa| heat shock 90kDa protein 1, alpha| heat shock 90kDa protein 1, beta| heat shock 90kD protein 1, alpha| heat shock 90kD protein 1, alpha-like 4| heat shock 90kD protein, alpha-like 4| heat shock protein, 1| heat shock protein 1, alpha| heat shock protein 86| heat shock protein, 86 kDa 1| heat shock protein, 89 kDa| heat shock protein-90| heat shock protein 90a| heat shock protein 90 alpha| heat shock protein 90, alpha (cytosolic), class A member 1| heat shock protein 90 kDa alpha class A member 1| heat shock protein 90kDa alpha, class A member 1| heat shock protein 90kDa alpha (cytosolic), class A member 1| heat shock protein 90kDa alpha family class A member 1| heat shock protein alpha| heat shock protein HSP90 alpha| Heat shock protein HSP 90-alpha| Heat shock protein HSP 90-alpha-like protein| HEL-S-65p| hsp4| Hsp86| HSP 86| Hsp86-1| Hsp89| HSP89A| Hsp90| Hsp90a| Hsp90 alpha| HSP90N| HSPC1| HSPCA| HSPCAL1| HSPCAL4| HSPN| I79_004665| LAP2| LAP-2| lipopolysaccharide-associated protein 2| LPS-associated protein 2| M959_08236| MDA_GLEAN10014950| N301_05453| N303_15491| N306_04643| N307_03868| N308_01594| N309_04351| N310_04086| N311_02435| N312_13591| N320_03538| N322_09611| N324_00363| N325_04739| N326_04823| N327_05413| N328_09587| N329_06909| N330_05883| N331_03988| N333_06148| N334_09678| N335_07341| N336_12683| PAL_GLEAN10020894| PANDA_016475| Putative heat shock protein HSP 90-beta-3| renal carcinoma antigen NY-REN-38| TREES_T100006806| TSTA| tumor-specific transplantation 86 kDa antigen| UY3_09959| Y1Q_029808| Y956_11615| Z169_09144| hsp90aa1

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