The Function of HSP90AA1
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
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Protein names
Recommended name:
Heat shock protein HSP 90-alphaShort name:
HSP86Alternative name(s):
Heat shock 86 kDaHSP 86
Lipopolysaccharide-associated protein 2
LAP-2
LPS-associated protein 2
Renal carcinoma antigen NY-REN-38
- RS1190596 (HSP90AA1) ??
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Top Gene-Substance Interactions
HSP90AA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSP90AA1
| Substances | Interaction | Organism | Category |
Substances That Decrease HSP90AA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Nucleotide Binding
- Glycoprotein Binding
- Utp Binding
- Ctp Binding
- Mrna Binding
- Protein Tyrosine Kinase Activity
- Atp Binding
- Gtp Binding
- Atpase Activity
- Mhc Class Ii Protein Complex Binding
- Nitric-Oxide Synthase Regulator Activity
- Tpr Domain Binding
- Datp Binding
- Identical Protein Binding
- Protein Homodimerization Activity
- Histone Deacetylase Binding
- Poly(A) Rna Binding
- Gtpase Binding
Biological Processes:
- G2/M Transition Of Mitotic Cell Cycle
- Neuron Migration
- Skeletal Muscle Contraction
- Mitochondrial Transport
- Receptor-Mediated Endocytosis
- Response To Unfolded Protein
- Signal Transduction
- Response To Heat
- Response To Cold
- Response To Salt Stress
- Positive Regulation Of Lamellipodium Assembly
- Cardiac Muscle Cell Apoptotic Process
- Regulation Of Protein Ubiquitination
- Positive Regulation Of Protein Import Into Nucleus, Translocation
- Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
- Erbb2 Signaling Pathway
- Protein Refolding
- Response To Cocaine
- Protein Unfolding
- Response To Estrogen
- Protein Import Into Mitochondrial Outer Membrane
- Positive Regulation Of Nitric Oxide Biosynthetic Process
- Positive Regulation Of Cell Size
- Response To Antibiotic
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Protein Stabilization
- Regulation Of Nitric-Oxide Synthase Activity
- Chaperone-Mediated Protein Complex Assembly
- Positive Regulation Of Cardiac Muscle Contraction
- Chaperone-Mediated Autophagy
- Regulation Of Cellular Response To Heat