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  3. HSD3B2

HSD3B2 (Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)

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The Function of HSD3B2

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

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Protein names

Recommended name:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Short name:

5

Alternative name(s):

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
3-beta-HSD II
3-beta-HSD adrenal and gonadal type
3-beta-hydroxy-5-ene steroid dehydrogenase
Progesterone reductase
Delta-5-3-ketosteroid isomerase

HSD3B2 SNPs

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  1. RS12141041 (HSD3B2) ??

Top Gene-Substance Interactions

HSD3B2 Interacts with These Diseases

Disease Score

Substances That Increase HSD3B2

Substances Interaction Organism Category

Substances That Decrease HSD3B2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • YY1

Tissue specificity:

Expressed in adrenal gland, testis and ovary.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Steroid hormones

Molecular Function:

  • 3-Beta-Hydroxy-Delta5-Steroid Dehydrogenase Activity
  • Steroid Delta-Isomerase Activity

Biological Processes:

  • Androgen Biosynthetic Process
  • Glucocorticoid Biosynthetic Process
  • Mineralocorticoid Biosynthetic Process
  • Steroid Biosynthetic Process

Drug Bank:

  • Corticotropin
  • Trilostane
  • Medroxyprogesterone Acetate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1| 3-beta-HSD| 3-beta-hydroxy-5-ene steroid dehydrogenase| 3-beta-hydroxy-Delta(5)-steroid dehydrogenase| 3 beta-hydroxysteroid dehydrogenase| 3-beta-hydroxysteroid dehydrogenase| 3 beta-hydroxysteroid dehydrogenase 1| 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase| HSD3B| progesterone reductase| hsd3b1| 3 beta hsd| 3-beta-HSD adrenal and gonadal type| 3-beta-HSD II| 3 beta-HSD type II| 3 beta-hydroxysteroid dehydrogenase 2| 3-beta-hydroxysteroid dehydrogenase 2| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II| 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II| 3b-HSD| delta 5-delta 4-isomerase type II| HSD3B2 protein| HSDB| hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1| hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1| hydroxysteroid dehydrogenase-2, delta<5>-3-beta| SDR11E2| short chain dehydrogenase/reductase family 11E, member 2| hsd3b2

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