The Function of HSD3B2
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
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Protein names
Recommended name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2Short name:
5Alternative name(s):
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II3-beta-HSD II
3-beta-HSD adrenal and gonadal type
3-beta-hydroxy-5-ene steroid dehydrogenase
Progesterone reductase
Delta-5-3-ketosteroid isomerase
- RS12141041 (HSD3B2) ??
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Top Gene-Substance Interactions
HSD3B2 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSD3B2
| Substances | Interaction | Organism | Category |
Substances That Decrease HSD3B2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in adrenal gland, testis and ovary.
Gene Pathways:
Molecular Function:
Biological Processes:
- Androgen Biosynthetic Process
- Glucocorticoid Biosynthetic Process
- Mineralocorticoid Biosynthetic Process
- Steroid Biosynthetic Process
Drug Bank:
- Corticotropin
- Trilostane
- Medroxyprogesterone Acetate