The Function of HSD17B6
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
Protein names
Recommended name:
17-beta-hydroxysteroid dehydrogenase type 6Alternative name(s):
17-beta-HSD 617-beta-HSD6
3-alpha->beta-hydroxysteroid epimerase
3-alpha->beta-HSE
Oxidative 3-alpha hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 9C member 6
- RS12367822 (HSD17B6) ??
- RS1391708 (HSD17B6) ??
- RS898611 (HSD17B6) ??
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Top Gene-Substance Interactions
HSD17B6 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSD17B6
| Substances | Interaction | Organism | Category |
Substances That Decrease HSD17B6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.
Gene Pathways:
Molecular Function:
- Catalytic Activity
- Estradiol 17-Beta-Dehydrogenase Activity
- Retinol Dehydrogenase Activity
- Electron Carrier Activity
- Oxidoreductase Activity
- Testosterone Dehydrogenase (Nad+) Activity