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  3. HSD17B6

HSD17B6 (Hydroxysteroid 17-beta dehydrogenase 6)

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The Function of HSD17B6

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.

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Protein names

Recommended name:

17-beta-hydroxysteroid dehydrogenase type 6

Alternative name(s):

17-beta-HSD 6
17-beta-HSD6
3-alpha->beta-hydroxysteroid epimerase
3-alpha->beta-HSE
Oxidative 3-alpha hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 9C member 6

HSD17B6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12367822 (HSD17B6) ??
  2. RS1391708 (HSD17B6) ??
  3. RS898611 (HSD17B6) ??

Top Gene-Substance Interactions

HSD17B6 Interacts with These Diseases

Disease Score

Substances That Increase HSD17B6

Substances Interaction Organism Category

Substances That Decrease HSD17B6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • AhR
  • NF-kappaB1
  • HSF2

Tissue specificity:

Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.

Gene Pathways:

  • Metabolic pathways
  • Steroid hormone biosynthesis
  • Disease
  • Signal Transduction

Molecular Function:

  • Catalytic Activity
  • Electron Carrier Activity
  • Estradiol 17-Beta-Dehydrogenase Activity
  • Oxidoreductase Activity
  • Retinol Dehydrogenase Activity
  • Testosterone Dehydrogenase (Nad+) Activity

Biological Processes:

  • Androgen Biosynthetic Process
  • Androgen Catabolic Process
  • Steroid Metabolic Process

Drug Bank:

  • Succinic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| retinol dehydrogenase| 17-beta-HSD6| 17-beta-HSD 6| 17betaHSD9| 17-beta-HSD9| 17-beta-hydroxysteroid dehydrogenase type 6| 3-alpha->beta-HSE| 3-alpha->beta-hydroxysteroid epimerase| 3(alpha->beta)-hydroxysteroid epimerase| 3(alpha->beta)-hydroxysteroid epimerasel| 3-hydroxysteroid epimerase| EGK_03816| GW7_15742| Hsd17b9| HSE| hydroxysteroid (17-beta) dehydrogenase 6| hydroxysteroid (17-beta) dehydrogenase 6 homolog| hydroxysteroid (17-beta) dehydrogenase 9| NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase| oxidative 17 beta hydroxysteroid dehydrogenase type 6| oxidative 3-alpha hydroxysteroid dehydrogenase| oxidative 3-alpha-hydroxysteroid-dehydrogenase| oxidoreductase| PANDA_004102| Rdh8| RODH| SDR9C6| short chain dehydrogenase/reductase family 9C member 6| TREES_T100006950| hsd17b6

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