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  3. HSD17B3

HSD17B3 (Hydroxysteroid 17-beta dehydrogenase 3)

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The Function of HSD17B3

Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.

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Protein names

Recommended name:

Testosterone 17-beta-dehydrogenase 3

Alternative name(s):

17-beta-hydroxysteroid dehydrogenase type 3
17-beta-HSD 3
Short chain dehydrogenase/reductase family 12C member 2
Testicular 17-beta-hydroxysteroid dehydrogenase

HSD17B3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7042315 (HSD17B3) ??
  2. RS8190560 (HSD17B3) ??
  3. RS8190569 (HSD17B3) ??
  4. RS9785234 (HSD17B3) ??

Top Gene-Substance Interactions

HSD17B3 Interacts with These Diseases

Disease Score

Substances That Increase HSD17B3

Substances Interaction Organism Category

Substances That Decrease HSD17B3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Tissue specificity:

Testis.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Steroid hormones

Molecular Function:

  • Testosterone 17-Beta-Dehydrogenase (Nadp+) Activity
  • Testosterone Dehydrogenase (Nad+) Activity

Biological Processes:

  • Androgen Biosynthetic Process
  • Male Genitalia Development
  • Testosterone Biosynthetic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 17beta-HSD| 17-beta-HSD3| 17-beta-HSD 3| 17(beta)HSD type 3| 17-beta hydroxysteroid dehydrogenase 3| 17-beta-hydroxysteroid dehydrogenase type 3| Anapl_16059| D623_10015815| DHB3| EDH17B3| estradiol 17 beta-dehydrogenase 3| GW7_00806| hydroxysteroid (17-beta) dehydrogenase 3| hydroxysteroid dehydrogenase 3| I79_025069| N300_12324| N307_11202| PAL_GLEAN10003689| PANDA_019690| SDR12C2| short chain dehydrogenase/reductase family 12C member 2| testicular 17-beta-hydroxysteroid dehydrogenase| Testosterone 17-beta-dehydrogenase 3| TREES_T100011275| Y1Q_003346| hsd17b3

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