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  3. HSD17B1

HSD17B1 (Hydroxysteroid 17-beta dehydrogenase 1)

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Summary of HSD17B1

The gene codes for a protein, hydroxysteroid 17-beta dehydrogenase 1. It is on chromosome 17 [R].

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The Function of HSD17B1

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Protein names

Recommended name:

Estradiol 17-beta-dehydrogenase 1

Short name:

E2DH

Alternative name(s):

17-beta-hydroxysteroid dehydrogenase type 1
17-beta-HSD 1
20 alpha-hydroxysteroid dehydrogenase
20-alpha-HSD
Placental 17-beta-hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 28C member 1

HSD17B1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS605059 (HSD17B1) ??

Top Gene-Substance Interactions

HSD17B1 Interacts with These Diseases

Disease Score

Substances That Increase HSD17B1

Substances Interaction Organism Category

Substances That Decrease HSD17B1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Steroid hormones
  • Disease
  • Signal Transduction

Molecular Function:

  • Catalytic Activity
  • Estradiol 17-Beta-Dehydrogenase Activity
  • Testosterone Dehydrogenase (Nad+) Activity

Biological Processes:

  • Bone Development
  • Cellular Response To Metal Ion
  • Estrogen Biosynthetic Process
  • Estrogen Metabolic Process
  • Steroid Biosynthetic Process
  • Testosterone Biosynthetic Process

Drug Bank:

  • Equilin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 20-alpha-HSD| 20 alpha-hydroxysteroid dehydrogenase| Estradiol 17-beta-dehydrogenase 1| 17-beta-dehydrogenase 1| 17-beta-HSD| 17beta-HSD| 17-beta-HSD 1| 17-beta hydroxysteroid dehydrogenase| 17-beta-hydroxysteroid dehydrogenase| 17-beta hydroxysteroid dehydrogenase 1| 17-beta hydroxysteroid dehydrogenase type 1| 17-beta-hydroxysteroid dehydrogenase type 1| 17beta hydroxysteroid dehydrogenase type 1| 17beta-hydroxysteroid dehydrogenase type 1| 17BHD1| 17HSDB1| AS27_11235| CB1_000194028| E2DH| edh17b2| EDHB17| EH28_20663| estradiol 17-beta-dehydrogenase 1-like protein| GW7_06849| HSD17| Hsd17ba| hydroxysteroid (17-beta) dehydrogenase 1| hydroxysteroid dehydrogenase 1| Hydroxysteroid dehydrogenase 17 beta, type 1| N303_00589| PAL_GLEAN10019520| PANDA_011161| placental 17-beta-hydroxysteroid dehydrogenase| sdr28c1| short chain dehydrogenase/reductase family 28CE, member 1| short chain dehydrogenase/reductase family 28C member 1| TREES_T100004504| UY3_02250| Y1Q_009246| zf 1.2| hsd17b1

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