Summary of HSD17B1
The gene codes for a protein, hydroxysteroid 17-beta dehydrogenase 1. It is on chromosome 17 [R].
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The Function of HSD17B1
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
Protein names
Recommended name:
Estradiol 17-beta-dehydrogenase 1Short name:
E2DHAlternative name(s):
17-beta-hydroxysteroid dehydrogenase type 117-beta-HSD 1
20 alpha-hydroxysteroid dehydrogenase
20-alpha-HSD
Placental 17-beta-hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 28C member 1
- RS605059 (HSD17B1) ??
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Top Gene-Substance Interactions
HSD17B1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSD17B1
| Substances | Interaction | Organism | Category |
Substances That Decrease HSD17B1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Catalytic Activity
- Estradiol 17-Beta-Dehydrogenase Activity
- Testosterone Dehydrogenase (Nad+) Activity
Biological Processes:
- Steroid Biosynthetic Process
- Estrogen Biosynthetic Process
- Estrogen Metabolic Process
- Bone Development
- Testosterone Biosynthetic Process
- Cellular Response To Metal Ion