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  3. HRH4

HRH4 (Histamine receptor H4)

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Summary of HRH4

The gene codes for a protein, histamine receptor H4. It may play a role in inflammation and allergy responses [R].

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The Function of HRH4

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).

Protein names

Recommended name:

Histamine H4 receptor

Short name:

H4R

Alternative name(s):

HH4R
AXOR35
G-protein coupled receptor 105
GPRv53
Pfi-013
SP9144

HRH4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11662595 (HRH4) ??
  2. RS11665084 (HRH4) ??

Top Gene-Substance Interactions

HRH4 Interacts with These Diseases

Disease Score

Substances That Increase HRH4

Substances Interaction Organism Category

Substances That Decrease HRH4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun

Tissue specificity:

Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Induction:

Expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL10/interleukin-10 or IL13/interleukin-13.

Molecular Function:

  • G-Protein Coupled Acetylcholine Receptor Activity
  • Histamine Receptor Activity

Biological Processes:

  • Adenylate Cyclase-Inhibiting G-Protein Coupled Acetylcholine Receptor Signaling Pathway
  • Inflammatory Response
  • Phospholipase C-Activating G-Protein Coupled Acetylcholine Receptor Signaling Pathway
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Regulation Of Mapk Cascade
  • Synaptic Transmission, Cholinergic

Drug Bank:

  • Amoxapine
  • Clozapine
  • Doxepin
  • Histamine Phosphate
  • Loxapine
  • Mianserin
  • Amitriptyline
  • Chlorpromazine
  • Olanzapine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| H4| hrh4| AXOR35| BG26| GPCR105| G-protein coupled receptor 105| GPRv53| H4R| HH4R| histamine 4 receptor| Histamine H3 receptor| histamine H3 receptor-like| Histamine H4 receptor| histamine receptor H4 subtype| M91_14547| N300_12924| N307_04093| N311_10856| N322_01771| N325_00382| N327_03242| N329_09128| PAL_GLEAN10023147| PANDA_000450| pfi-013| SP9144| TREES_T100019915| Y956_04656

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