Summary of HRH4
The Function of HRH4
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Protein names
Recommended name:
Histamine H4 receptorShort name:
H4RAlternative name(s):
HH4RAXOR35
G-protein coupled receptor 105
GPRv53
Pfi-013
SP9144
- RS11662595 (HRH4) ??
- RS11665084 (HRH4) ??
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Top Gene-Substance Interactions
HRH4 Interacts with These Diseases
| Disease | Score |
Substances That Increase HRH4
| Substances | Interaction | Organism | Category |
Substances That Decrease HRH4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
Gene Pathways:
Induction:
Expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL10/interleukin-10 or IL13/interleukin-13.
Molecular Function:
Biological Processes:
- Inflammatory Response
- Adenylate Cyclase-Inhibiting G-Protein Coupled Acetylcholine Receptor Signaling Pathway
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Phospholipase C-Activating G-Protein Coupled Acetylcholine Receptor Signaling Pathway
- Synaptic Transmission, Cholinergic
- Regulation Of Mapk Cascade
Drug Bank:
- Amoxapine
- Clozapine
- Doxepin
- Histamine Phosphate
- Loxapine
- Mianserin
- Amitriptyline
- Chlorpromazine
- Olanzapine