Summary of HPSE
The gene codes for a protein, heparanase. It aids with cell movement through the extracellular matrix [R].
The Function of HPSE
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Protein names
Recommended name:
HeparanaseAlternative name(s):
Endo-glucoronidaseHeparanase-1
Hpa1
- RS11099592 (HPSE) ??
- RS4364254 (HPSE) ??
- RS4693608 (HPSE) ??
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Top Gene-Substance Interactions
HPSE Interacts with These Diseases
| Disease | Score |
Substances That Increase HPSE
| Substances | Interaction | Organism | Category |
Substances That Decrease HPSE
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase.
Gene Pathways:
Enzyme Regulation:
Inhibited by EDTA, laminarin sulfate and, to a lower extent, by heparin and sulfamin and activated by calcium and magnesium.
Molecular Function:
- Beta-Glucuronidase Activity
- Heparanase Activity
- Heparan Sulfate Proteoglycan Binding
- Syndecan Binding
- Protein Dimerization Activity
Biological Processes:
- Carbohydrate Metabolic Process
- Glycosaminoglycan Catabolic Process
- Proteoglycan Metabolic Process
- Cell-Matrix Adhesion
- Positive Regulation Of Vascular Endothelial Growth Factor Production
- Positive Regulation Of Blood Coagulation
- Extracellular Matrix Organization
- Heparan Sulfate Proteoglycan Catabolic Process
- Positive Regulation Of Osteoblast Proliferation
- Regulation Of Hair Follicle Development
- Positive Regulation Of Hair Follicle Development
- Positive Regulation Of Protein Kinase B Signaling
- Angiogenesis Involved In Wound Healing
- Vascular Wound Healing