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HPSE (Heparanase)

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Summary of HPSE

The gene codes for a protein, heparanase. It aids with cell movement through the extracellular matrix [R].

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The Function of HPSE

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

Protein names

Recommended name:

Heparanase

Alternative name(s):

Endo-glucoronidase
Heparanase-1
Hpa1

HPSE SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11099592 (HPSE) ??
  2. RS4364254 (HPSE) ??
  3. RS4693608 (HPSE) ??

Top Gene-Substance Interactions

HPSE Interacts with These Diseases

Disease Score

Substances That Increase HPSE

Substances Interaction Organism Category

Substances That Decrease HPSE

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • Egr-1
  • CREB
  • deltaCREB
  • NF-kappaB1
  • AREB6

Tissue specificity:

Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Glycosaminoglycan degradation

Enzyme Regulation:

Inhibited by EDTA, laminarin sulfate and, to a lower extent, by heparin and sulfamin and activated by calcium and magnesium.

Molecular Function:

  • Beta-Glucuronidase Activity
  • Heparanase Activity
  • Heparan Sulfate Proteoglycan Binding
  • Protein Dimerization Activity
  • Syndecan Binding

Biological Processes:

  • Angiogenesis Involved In Wound Healing
  • Carbohydrate Metabolic Process
  • Cell-Matrix Adhesion
  • Extracellular Matrix Organization
  • Glycosaminoglycan Catabolic Process
  • Heparan Sulfate Proteoglycan Catabolic Process
  • Positive Regulation Of Blood Coagulation
  • Positive Regulation Of Hair Follicle Development
  • Positive Regulation Of Osteoblast Proliferation
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Vascular Endothelial Growth Factor Production
  • Proteoglycan Metabolic Process
  • Regulation Of Hair Follicle Development
  • Vascular Wound Healing

Drug Bank:

  • Heparin
  • Dalteparin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12441| AS27_05732| AS28_03145| EH28_11031| endo-glucoronidase| endoglycosidase heparanase| GW7_21096| H920_00229| Hep| heparanase-1| heparanase-like| HPA| HPA1| Hpr1| HPSE1| hse1| I79_020442| M91_00811| M959_05164| N300_03081| N302_06069| N303_09485| N305_05242| N306_02754| N308_05700| N309_03190| N311_09782| N312_08439| N320_05628| N321_05585| N322_08690| N324_08180| N325_12247| N326_11523| N327_02903| N328_12329| N329_10098| N330_06759| N331_02579| N332_14261| N333_06308| N334_11517| N335_03521| N340_00435| N341_12165| PANDA_000255| Para-hydroxybenzoate--polyprenyltransferase, mitochondrial| TREES_T100007734| Y1Q_008270| Y956_11698| Z169_13684| hpse

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