The Function of HPGDS
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
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Protein names
Recommended name:
Hematopoietic prostaglandin D synthaseShort name:
H-PGDSAlternative name(s):
GST class-sigmaGlutathione S-transferase
Glutathione-dependent PGD synthase
Glutathione-requiring prostaglandin D synthase
Prostaglandin-H2 D-isomerase
- RS17021463 (HPGDS) ??
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Top Gene-Substance Interactions
HPGDS Interacts with These Diseases
| Disease | Score |
Substances That Increase HPGDS
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Substances That Decrease HPGDS
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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