The Function of HP
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
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Protein names
Recommended name:
HaptoglobinAlternative name(s):
ZonulinTop Gene-Substance Interactions
HP Interacts with These Diseases
| Disease | Score |
Substances That Increase HP
| Substances | Interaction | Organism | Category |
Substances That Decrease HP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed by the liver and secreted in plasma.
Caution:
Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.
Molecular Function:
Biological Processes:
- Immune System Process
- Receptor-Mediated Endocytosis
- Defense Response
- Acute-Phase Response
- Positive Regulation Of Cell Death
- Response To Hydrogen Peroxide
- Defense Response To Bacterium
- Negative Regulation Of Oxidoreductase Activity
- Negative Regulation Of Hydrogen Peroxide Catabolic Process