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  3. HP

HP (Haptoglobin)

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The Function of HP

Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

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Protein names

Recommended name:

Haptoglobin

Alternative name(s):

Zonulin

Top Gene-Substance Interactions

HP Interacts with These Diseases

Disease Score

Substances That Increase HP

Substances Interaction Organism Category

Substances That Decrease HP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • Nkx2-5
  • C/EBPalpha
  • STAT5A
  • STAT5B

Tissue specificity:

Expressed by the liver and secreted in plasma.

Caution:

Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.

Molecular Function:

  • Antioxidant Activity
  • Hemoglobin Binding

Biological Processes:

  • Acute-Phase Response
  • Defense Response
  • Defense Response To Bacterium
  • Immune System Process
  • Negative Regulation Of Hydrogen Peroxide Catabolic Process
  • Negative Regulation Of Oxidoreductase Activity
  • Positive Regulation Of Cell Death
  • Receptor-Mediated Endocytosis
  • Response To Hydrogen Peroxide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

HP-1| Ba1-647| binding peptide| BP| haptoglobin alpha 1S| haptoglobin alpha(1S)-beta| haptoglobin alpha(2FS)-beta| haptoglobin, alpha polypeptide| haptoglobin, beta polypeptide| haptoglobin isoform 2 preproprotein| haptoglobin preproprotein| haptoglobin-related protein| HP2ALPHA2| HPA1S| HpL| HPR| humped| liver regeneration-related protein LRRG173| MDA_GLEAN10016792| preHP2| Zonulin| hp

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