Summary of HOPX
The gene codes for a protein, HOP homeobox. It is necessary for DNA binding [R].
The Function of HOPX
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
Protein names
Recommended name:
Homeodomain-only proteinAlternative name(s):
Lung cancer-associated Y proteinNot expressed in choriocarcinoma protein 1
Odd homeobox protein 1
- RS4371677 (HOPX) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase HOPX
| Substances | Interaction | Organism | Category |
Substances That Decrease HOPX
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
Molecular Function:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Trophectodermal Cell Differentiation
- Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Heart Development
- Regulation Of Heart Contraction
- Histone Deacetylation
- Positive Regulation Of Skeletal Muscle Tissue Regeneration
- Negative Regulation Of Cell Differentiation
- Lung Alveolus Development
- Positive Regulation Of Striated Muscle Cell Differentiation