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  3. HOPX

HOPX (HOP homeobox)

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Summary of HOPX

The gene codes for a protein, HOP homeobox. It is necessary for DNA binding [R].

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The Function of HOPX

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.

Protein names

Recommended name:

Homeodomain-only protein

Alternative name(s):

Lung cancer-associated Y protein
Not expressed in choriocarcinoma protein 1
Odd homeobox protein 1

HOPX SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4371677 (HOPX) ??

Top Gene-Substance Interactions

Substances That Increase HOPX

Substances Interaction Organism Category

Substances That Decrease HOPX

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • C/EBPalpha
  • STAT5A
  • HNF-3beta

Tissue specificity:

Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.

Molecular Function:

  • Dna Binding

Biological Processes:

  • Heart Development
  • Histone Deacetylation
  • Lung Alveolus Development
  • Negative Regulation Of Cell Differentiation
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Skeletal Muscle Tissue Regeneration
  • Positive Regulation Of Striated Muscle Cell Differentiation
  • Regulation Of Heart Contraction
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated
  • Trophectodermal Cell Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_13328| AS27_12804| AS28_13236| cameo| GIIg15b| global ischemia-induced gene 15B protein| global ischemia-induced protein 15B| global ischemia induced protein GIIG15B| H920_01213| Hdop| HOD| homeobox only domain| homeobox-only protein| homeobox protein goosecoid-like| homeodomain-only protein| homeodomain-only protein pseudogene| Homeodomain-related containing protein| HOP| I79_024591| LAGY| lung cancer-associated Y protein| M959_02771| MDA_GLEAN10015812| mOB1| N300_14938| N301_13149| N302_04289| N303_00911| N305_00519| N306_02828| N307_03777| N309_13536| N310_08865| N311_03233| N320_07933| N321_02389| N324_08675| N325_01981| N326_10234| N327_07016| N328_08288| N330_10165| N331_04337| N332_14076| N334_14105| N335_05268| N340_10636| necc1| not expressed in choriocarcinoma clone 1| Ob1| Obl| odd homeobox 1| odd homeobox 1 protein| odd homeobox protein 1| PAL_GLEAN10016131| PANDA_006558| smap31| toto| TREES_T100016528| UY3_17348| Y1Q_024361| Y956_01000| Z169_07565| hopx

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