Summary of HOMER1
Increased expression of Homer1a in the hippocampus led to an increased vulnerability to chronic stress and depression-like behavior (R).
HOMER1 influences the activity of metabotropic glutamate receptor 5 (mGluR5) and it's likely through this receptor by which HOMER1 can increase the risk of depression. Blocking these receptors has antidepressant properties (R).
Protein names
Recommended name:
Homer protein homolog 1Alternative name(s):
Homer-1- RS10078095 (HOMER1) ??
- RS6859667 (HOMER1) ??
- RS7713917 (HOMER1) ??
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Top Gene-Substance Interactions
HOMER1 Interacts with These Diseases
| Disease | Score |
Fixes
Risk factors in the HOMER1 gene may contribute to depression by over-activating the brain’s glutamate system (mGluR5 glutamate receptors), which has been linked to increased vulnerability to chronic stress and depression-like behavior in mice [R]. Conversely, blocking these receptors has anti-depressant effects in both humans and animals [R].
Therefore, you may be able to counteract your risk by drinking Pu-erh tea, which decreases the production of mGluR5 glutamate receptors. These are the same receptors that are activated by HOMER1 [R].
Another way to potentially counteract your risk would be to supplement with lithium. Lithium blocks the activity of mGluR5 glutamate receptors, causing an anti-depressant effect [R]. Multiple studies have even found that places with more lithium in the water supply have lower suicide rates, which is most likely due to its ability to alleviate depression symptoms in general [R, R].
Vitamin E may decrease HOMER1 expression (unverified) (R).
Substances That Increase HOMER1
| Substances | Interaction | Organism | Category |
Substances That Decrease HOMER1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Skeletal Muscle Contraction
- Phospholipase C-Activating G-Protein Coupled Glutamate Receptor Signaling Pathway
- Chemical Synaptic Transmission
- Positive Regulation Of Signal Transduction
- Behavioral Response To Cocaine
- Skeletal Muscle Fiber Development
- Chemical Homeostasis Within A Tissue
- Response To Calcium Ion
- Positive Regulation Of Calcium Ion Transport
- Regulation Of Calcium Ion Import
- Regulation Of Store-Operated Calcium Entry
- Regulation Of Cation Channel Activity