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  3. HOMER1

HOMER1 (Homer scaffolding protein 1)

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Summary of HOMER1

Increased expression of Homer1a in the hippocampus led to an increased vulnerability to chronic stress and depression-like behavior (R).

HOMER1 influences the activity of metabotropic glutamate receptor 5 (mGluR5) and it's likely through this receptor by which HOMER1 can increase the risk of depression. Blocking these receptors has antidepressant properties (R).

It's better to have this gene decreased most of the time.
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Protein names

Recommended name:

Homer protein homolog 1

Alternative name(s):

Homer-1

HOMER1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10078095 (HOMER1) ??
  2. RS6859667 (HOMER1) ??
  3. RS7713917 (HOMER1) ??

Top Gene-Substance Interactions

HOMER1 Interacts with These Diseases

Disease Score

Fixes

Risk factors in the HOMER1 gene may contribute to depression by over-activating the brain’s glutamate system (mGluR5 glutamate receptors), which has been linked to increased vulnerability to chronic stress and depression-like behavior in mice [R]. Conversely, blocking these receptors has anti-depressant effects in both humans and animals [R].

Therefore, you may be able to counteract your risk by drinking Pu-erh tea, which decreases the production of mGluR5 glutamate receptors. These are the same receptors that are activated by HOMER1 [R].

Another way to potentially counteract your risk would be to supplement with lithium. Lithium blocks the activity of mGluR5 glutamate receptors, causing an anti-depressant effect [R]. Multiple studies have even found that places with more lithium in the water supply have lower suicide rates, which is most likely due to its ability to alleviate depression symptoms in general [R, R].

Vitamin E may decrease HOMER1 expression (unverified) (R).

Substances That Increase HOMER1

Substances Interaction Organism Category

Substances That Decrease HOMER1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

  • Glutamatergic synapse

Molecular Function:

  • G-Protein Coupled Glutamate Receptor Binding
  • Ion Channel Binding
  • Signaling Adaptor Activity

Biological Processes:

  • Behavioral Response To Cocaine
  • Chemical Homeostasis Within A Tissue
  • Chemical Synaptic Transmission
  • Phospholipase C-Activating G-Protein Coupled Glutamate Receptor Signaling Pathway
  • Positive Regulation Of Calcium Ion Transport
  • Positive Regulation Of Signal Transduction
  • Regulation Of Calcium Ion Import
  • Regulation Of Cation Channel Activity
  • Regulation Of Store-Operated Calcium Entry
  • Response To Calcium Ion
  • Skeletal Muscle Contraction
  • Skeletal Muscle Fiber Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04953| AS27_09948| AS28_06244| CB1_000917030| D623_10035981| H920_01510| homer| homer 1| homer-1| homer1a| homer1b| homer1c| HOMER1F| homer homolog 1| homer-like protein 1| Homer like protein 1| homer, neuronal immediate early gene, 1| Homer protein 1| homer protein 1-like protein| homer protein homolog 1| homer protein-like 1| Homer protein like protein 1| Homer protein-like protein 1| immediate early gene protein Homer1A| M91_15738| M959_08798| N300_04321| N301_04099| N302_14991| N303_10479| N305_14713| N306_11187| N307_11859| N308_15600| N309_13472| N322_11794| N329_09490| N330_08240| N334_04655| N340_02360| N341_12195| PAL_GLEAN10024931| PANDA_004319| PSD-Zip45| scaffold protein| SYN47| TREES_T100019313| UY3_13607| VASP/Ena-related gene up-regulated during seizure and LTP 1| Ves-1| Vesl-1| xhomer1| Y1Q_010735| Y956_08406| Z169_10285| homer1

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