Summary of HMOX1
HMOX1 is important for producing an enzyme that helps combat free radicals.
Enhanced production may contribute to disease as well by depositing too much iron (R).
Impaired HMOX1 activity could reduce the neuronal production of biliverdin/bilirubin metabolites, which exert an antioxidant role (R).
HMOX1 is a gene that produces the enzyme Heme oxygenase-1 (HO-1). Heme oxygenase-1 (HO-1) is an enzyme that helps degrade heme into biliverdin, iron, and carbon monoxide (R). HO-1 was suggested to have an anti-oxidative stress, anti-inflammatory, and anti-cancer effect. It helps protect cells from dying as well.
The mechanisms are via carbon monoxide, biliverdin, and iron (R). Heme oxygenase is induced by oxidative stress, and in animal models increasing this gene expression seems to be protective (R). Carbon monoxide released from heme oxygenase reactions can relax blood vessels independently or influence the function of nitric oxide synthesis (R).
Enhanced production may contribute to disease as well by depositing too much iron (R).
Impaired HMOX1 activity could reduce the neuronal production of biliverdin/bilirubin metabolites, which exert an antioxidant role (R).
HO-1 is essential for heme degradation by producing bile pigments, ferritin, and carbon monoxide (R). HO-1 helps close tight junctions to help with leaky gut. HO-1 increases IFNb (R), Bilirubin(R), Carbon Monoxide, IL-10 and IL-1a (R).
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Heme oxygenase 1 deficiency (HMOX1D): A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. [MIM:614034]
From NCBI Gene: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008] From UniProt: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Protein names
Recommended name:
Heme oxygenase 1Short name:
HO-1- RS2071746 (HMOX1) ??
- RS2071747 (HMOX1) ??
- RS2071748 (HMOX1) ??
- RS5755703 (HMOX1) ??
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Top Gene-Substance Interactions
HMOX1 Interacts with These Diseases
Disease | Score |
Fixes
Substances That Increase HMOX1
Substances | Interaction | Organism | Category |
Substances That Decrease HMOX1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Gene Pathways:
Induction:
Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.
Molecular Function:
- Enzyme Binding
- Heme Binding
- Heme Oxygenase (Decyclizing) Activity
- Metal Ion Binding
- Phospholipase D Activity
- Protein Homodimerization Activity
- Signal Transducer Activity
Biological Processes:
- Angiogenesis
- Cell Death
- Cellular Iron Ion Homeostasis
- Cellular Response To Arsenic-Containing Substance
- Cellular Response To Cadmium Ion
- Cellular Response To Cisplatin
- Cellular Response To Heat
- Cellular Response To Hypoxia
- Cellular Response To Nutrient
- Endothelial Cell Proliferation
- Erythrocyte Homeostasis
- Excretion
- Heme Catabolic Process
- Heme Oxidation
- Intracellular Signal Transduction
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Iron Ion Homeostasis
- Liver Regeneration
- Low-Density Lipoprotein Particle Clearance
- Negative Regulation Of Dna Binding
- Negative Regulation Of Epithelial Cell Apoptotic Process
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Leukocyte Migration
- Negative Regulation Of Mast Cell Cytokine Production
- Negative Regulation Of Mast Cell Degranulation
- Negative Regulation Of Muscle Cell Apoptotic Process
- Negative Regulation Of Neuron Apoptotic Process
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Negative Regulation Of Vascular Smooth Muscle Cell Proliferation
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Chemokine Biosynthetic Process
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Macroautophagy
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Vasodilation
- Protein Homooligomerization
- Regulation Of Angiogenesis
- Regulation Of Blood Pressure
- Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Iron
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Oxidative Stress
- Response To Estrogen
- Response To Hydrogen Peroxide
- Response To Nicotine
- Response To Oxidative Stress
- Small Gtpase Mediated Signal Transduction
- Smooth Muscle Hyperplasia
- Wound Healing Involved In Inflammatory Response