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  3. HMMR

HMMR (Hyaluronan mediated motility receptor)

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Summary of HMMR

The gene codes for a protein, hyaluronan mediated motility receptor. It is found in breast tissue, and it forms a complex with BRCA1 and BRCA2. Therefore, it is linked to a higher risk of breast cancer [R].

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The Function of HMMR

Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

Protein names

Recommended name:

Hyaluronan mediated motility receptor

Alternative name(s):

Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD antigen CD168

HMMR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10515860 (HMMR) ??
  2. RS13183712 (HMMR) ??
  3. RS299284 (HMMR) ??
  4. RS299290 (HMMR) ??
  5. RS3756648 (HMMR) ??
  6. RS7712023 (HMMR) ??

Top Gene-Substance Interactions

HMMR Interacts with These Diseases

Disease Score

Substances That Increase HMMR

Substances Interaction Organism Category

Substances That Decrease HMMR

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Familial cancer of breast

     From NCBI Gene: The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer . Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008] From UniProt: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CUTL1
  • NF-kappaB1
  • STAT5A
  • c-Myc
  • IRF-2
  • Cdc5
  • HNF-3beta

Tissue specificity:

Expressed in breast cancer cell lines and in normal breast tissue.

Gene Pathways:

  • Metabolism
  • Disease

Molecular Function:

  • Hyaluronic Acid Binding

Biological Processes:

  • G2/M Transition Of Mitotic Cell Cycle
  • Hyaluronan Catabolic Process

Drug Bank:

  • Hyaluronic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| RHAMM| A306_14629| Anapl_17102| AS27_11856| AS28_10299| CD168| D623_10034864| hyaluronan-mediated motility receptor| Hyaluronan mediated motility receptor-like protein| hyaluronan mediated motility receptor (RHAMM)| hyaluronan-mediated motility receptor (RHAMM)| hyaluronic acid-mediated motility receptor| IHABP| intracellular hyaluronic acid-binding protein| M959_08283| MDA_GLEAN10025755| N300_13090| N301_04998| N302_07124| N305_06785| N307_00712| N308_13119| N309_13086| N310_06025| N311_05551| N312_07646| N320_09590| N321_00268| N322_03436| N324_07807| N325_00326| N327_07538| N328_07777| N329_07919| N330_13253| N331_09022| N332_02829| N333_04042| N334_06168| N335_00242| N336_07335| N339_03964| N340_00688| N341_01288| PAL_GLEAN10018851| PANDA_016527| receptor for hyaluronan-mediated motility| receptor for hyaluronic acid mediated motility| xrhamm| Y1Q_018330| Y956_14127| Z169_04273| hmmr

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