Summary of HMMR
The gene codes for a protein, hyaluronan mediated motility receptor. It is found in breast tissue, and it forms a complex with BRCA1 and BRCA2. Therefore, it is linked to a higher risk of breast cancer [R].
The Function of HMMR
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
Protein names
Recommended name:
Hyaluronan mediated motility receptorAlternative name(s):
Intracellular hyaluronic acid-binding proteinReceptor for hyaluronan-mediated motility
CD antigen CD168
- RS10515860 (HMMR) ??
- RS13183712 (HMMR) ??
- RS299284 (HMMR) ??
- RS299290 (HMMR) ??
- RS3756648 (HMMR) ??
- RS7712023 (HMMR) ??
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Top Gene-Substance Interactions
HMMR Interacts with These Diseases
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Substances That Increase HMMR
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Substances That Decrease HMMR
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Advanced Summary
From NCBI Gene: Familial cancer of breast
From NCBI Gene: The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer . Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008] From UniProt: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in breast cancer cell lines and in normal breast tissue.