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  3. HMGCR

HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)

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Summary of HMGCR

This gene encodes an enzyme that catalyzes the rate limiting step in cholesterol biosynthesis (R). 

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The Function of HMGCR

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Protein names

Recommended name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Alternative name(s):

HMG-CoA reductase

HMGCR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10038095 (HMGCR) ??
  2. RS10045497 (HMGCR) ??
  3. RS12654264 (HMGCR) ??
  4. RS12916 (HMGCR) ??
  5. RS17238540 (HMGCR) ??
  6. RS17244841 (HMGCR) ??
  7. RS3761740 (HMGCR) ??
  8. RS3843482 (HMGCR) ??
  9. RS3846662 (HMGCR) ??
  10. RS3846663 (HMGCR) ??
  11. RS5908 (HMGCR) ??
  12. RS6871667 (HMGCR) ??
  13. RS7703051 (HMGCR) ??

Top Gene-Substance Interactions

HMGCR Interacts with These Diseases

Disease Score

Substances That Increase HMGCR

Substances Interaction Organism Category

Substances That Decrease HMGCR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • PPAR-alpha
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Terpenoid backbone biosynthesis
  • Bile secretion

Enzyme Regulation:

Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate. Inhibited by statins, a class of hypolipidemic agents used as pharmaceuticals to lower cholesterol levels in individuals at risk from cardiovascular disease due to hypercholesterolemia. Inhibition of HMGCR in the liver stimulates the LDL-receptors, which results in an increased clearance of LDL from the bloodstream and a decrease in blood cholesterol levels. The first results can be seen after one week of statin use and the effect is maximal after four to six weeks.

Molecular Function:

  • Coenzyme Binding
  • Hydroxymethylglutaryl-Coa Reductase (Nadph) Activity
  • Hydroxymethylglutaryl-Coa Reductase Activity
  • Nadph Binding

Biological Processes:

  • Aging
  • Cholesterol Biosynthetic Process
  • Coenzyme A Metabolic Process
  • Isoprenoid Biosynthetic Process
  • Myoblast Differentiation
  • Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
  • Negative Regulation Of Map Kinase Activity
  • Negative Regulation Of Striated Muscle Cell Apoptotic Process
  • Negative Regulation Of Vasodilation
  • Negative Regulation Of Wound Healing
  • Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Skeletal Muscle Tissue Development
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Stress-Activated Mapk Cascade
  • Protein Tetramerization
  • Response To Ethanol
  • Response To Nutrient
  • Ubiquinone Metabolic Process
  • Visual Learning

Drug Bank:

  • Rosuvastatin
  • Fluvastatin
  • Lovastatin
  • Pitavastatin
  • Pravastatin
  • Simvastatin
  • Atorvastatin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 3-alpha-hydroxy-3-methylglutaryl-CoA reductase| 3H3M| 3-Hydroxy-3-Methylglutaryl CoA reductase| 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)| 3-hydroxy-3-methylglutaryl coenzyme A reductase| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase| 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase| AS27_09921| AS28_06214| BcDNA:LD15354| bro1| bs32f05.y1| CB1_001305003| CG10367 gene product from transcript CG10367-RA| CG10367-PA| clb| columbus| Dmel_CG10367| DmHMG-CoAr| EH28_14673| GW7_02857| H920_03178| Hmg| hmgc| hmg-coa-r| HMGCoAr| HMG-CoAR| Hmg-CoA-reductase| HMG-CoA reductase| HMGCo-A reductase| HMGCoA reductase| HMG-CoA reductase class I| HMGCoARr| HMG coenzyme A reductase| HMGCR_Dm| Hmgcr-PA| HMGR| hmgrc| hydroxymethylglutaryl-CoA reductase| I79_015809| LDLCQ3| lethal (3) 04684| M959_03621| N300_04348| N301_04125| N302_11257| N303_00950| N305_02340| N306_04943| N307_02013| N308_15576| N309_01990| N312_08448| N320_10412| N321_01338| N322_02684| N324_09684| N325_06869| N326_03322| N327_02922| N328_01462| N329_10670| N330_10499| N331_07341| N332_02789| N333_12249| N334_07186| N335_13900| N336_10477| N339_02909| N340_01496| N341_05525| PAL_GLEAN10024896| PANDA_005466| Red| TREES_T100006973| UY3_11446| Y1Q_011028| Z169_10263| hmgcr

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