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  3. HMGA1

HMGA1 (High mobility group AT-hook 1)

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The Function of HMGA1

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

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Protein names

Recommended name:

High mobility group protein HMG-I/HMG-Y

Short name:

HMG-I(Y

Alternative name(s):

High mobility group AT-hook protein 1
High mobility group protein A1
High mobility group protein R

HMGA1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12214804 (HMGA1) ??
  2. RS1759645 (HMGA1) ??
  3. RS1776897 (HMGA1) ??
  4. RS2780226 (HMGA1) ??
  5. RS7742369 (HMGA1) ??

Top Gene-Substance Interactions

HMGA1 Interacts with These Diseases

Disease Score

Substances That Increase HMGA1

Substances Interaction Organism Category

Substances That Decrease HMGA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • Sp1
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Gene Pathways:

  • Disease
  • Cellular responses to stress

Molecular Function:

  • 5'-Deoxyribose-5-Phosphate Lyase Activity
  • At Dna Binding
  • Chromatin Binding
  • Dna-(Apurinic Or Apyrimidinic Site) Lyase Activity
  • Dna Binding
  • Enzyme Binding
  • Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
  • Peroxisome Proliferator Activated Receptor Binding
  • Retinoic Acid Receptor Binding
  • Retinoid X Receptor Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding

Biological Processes:

  • Base-Excision Repair
  • Dna Unwinding Involved In Dna Replication
  • Establishment Of Integrated Proviral Latency
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Chromatin Silencing
  • Negative Regulation Of Transcription, Dna-Templated
  • Nuclear Transport
  • Nucleosome Disassembly
  • Oncogene-Induced Cell Senescence
  • Positive Regulation Of Cellular Senescence
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Complex Assembly
  • Regulation Of Transcription, Dna-Templated
  • Response To Virus
  • Senescence-Associated Heterochromatin Focus Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14740| AL023995| CB1_000487026| H920_15473| high mobility group AT-hook protein 1| high mobility group HMGA1A| high mobility group HMGA1B| high mobility group-I protein| high-mobility group (nonhistone chromosomal) protein isoforms I and Y| high mobility group protein| high mobility group protein 1A| high mobility group protein A1| High mobility group protein HMG-I/HMG-Y| high mobility group protein I| high mobility group protein R| Hmga1a| Hmga1b| Hmgi| Hmg-i| HMGIY| HMG-I(Y)| HMG-R| Hmgy| HMG-Y| M91_15538| MDA_GLEAN10005157| nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y| non-histone protein| PAL_GLEAN10007082| PANDA_002251| TREES_T100009681| hmga1

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