The Function of HMGA1
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
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Protein names
Recommended name:
High mobility group protein HMG-I/HMG-YShort name:
HMG-I(YAlternative name(s):
High mobility group AT-hook protein 1High mobility group protein A1
High mobility group protein R
- RS12214804 (HMGA1) ??
- RS1759645 (HMGA1) ??
- RS1776897 (HMGA1) ??
- RS2780226 (HMGA1) ??
- RS7742369 (HMGA1) ??
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Top Gene-Substance Interactions
HMGA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HMGA1
| Substances | Interaction | Organism | Category |
Substances That Decrease HMGA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Dna Binding
- At Dna Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Dna-(Apurinic Or Apyrimidinic Site) Lyase Activity
- Transcription Factor Binding
- Enzyme Binding
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Retinoic Acid Receptor Binding
- Peroxisome Proliferator Activated Receptor Binding
- Retinoid X Receptor Binding
- 5'-Deoxyribose-5-Phosphate Lyase Activity
Biological Processes:
- Dna Unwinding Involved In Dna Replication
- Base-Excision Repair
- Nucleosome Disassembly
- Regulation Of Transcription, Dna-Templated
- Protein Complex Assembly
- Negative Regulation Of Cell Proliferation
- Response To Virus
- Negative Regulation Of Chromatin Silencing
- Senescence-Associated Heterochromatin Focus Assembly
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Nuclear Transport
- Establishment Of Integrated Proviral Latency
- Oncogene-Induced Cell Senescence
- Positive Regulation Of Cellular Senescence