• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. HLA-DQA1

HLA-DQA1 (Major histocompatibility complex, class II, DQ alpha 1)

Loading...

Summary of HLA-DQA1

The HLA-DQA1 gene codes for major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1). HLA-DQA1 combines with another protein to form a human leukocyte antigen (HLA) protein [R]. 

HLA proteins are receptors found on the surface of white blood cells. They help flag and remove agents that can harm the body or cause infections [R, R].

Changes in the structure of HLA proteins can cause them to mistakenly flag our own proteins (autoimmunity) or flag harmless substances (allergies) [R, R].

HLA-DQA1 variants have been linked to many conditions, including [R, R, R]:

  • Alopecia
  • Type 1 diabetes
  • Allergies
  • Celiac disease
0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

HLA class II histocompatibility antigen, DQ alpha 1 chain

Short name:

HLA-DCA

Alternative name(s):

DC-1 alpha chain
DC-alpha
MHC class II DQA1

HLA-DQA1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS113653754 (HLA-DQA1) ??
  2. RS1800683 (HLA-DQA1) ??
  3. RS2009658 (HLA-DQA1) ??
  4. RS2040406 (HLA-DQA1) ??
  5. RS204999 (HLA-DQA1) ??
  6. RS2187668 (HLA-DQA1) ??
  7. RS2239704 (HLA-DQA1) ??
  8. RS28421666 (HLA-DQA1) ??
  9. RS2844482 (HLA-DQA1) ??
  10. RS2857708 (HLA-DQA1) ??
  11. RS2858870 (HLA-DQA1) ??
  12. RS3021304 (HLA-DQA1) ??
  13. RS3104413 (HLA-DQA1) ??
  14. RS3129763 (HLA-DQA1) ??
  15. RS3135388 (HLA-DQA1) ??
  16. RS35597309 (HLA-DQA1) ??
  17. RS3957148 (HLA-DQA1) ??
  18. RS4530903 (HLA-DQA1) ??
  19. RS4713555 (HLA-DQA1) ??
  20. RS477515 (HLA-DQA1) ??
  21. RS602875 (HLA-DQA1) ??
  22. RS615672 (HLA-DQA1) ??
  23. RS6457617 (HLA-DQA1) ??
  24. RS660895 (HLA-DQA1) ??
  25. RS674313 (HLA-DQA1) ??
  26. RS6906021 (HLA-DQA1) ??
  27. RS6927022 (HLA-DQA1) ??
  28. RS6931277 (HLA-DQA1) ??
  29. RS7454108 (HLA-DQA1) ??
  30. RS746868 (HLA-DQA1) ??
  31. RS76901167 (HLA-DQA1) ??
  32. RS7744020 (HLA-DQA1) ??
  33. RS7762619 (HLA-DQA1) ??
  34. RS915654 (HLA-DQA1) ??
  35. RS9268528 (HLA-DQA1) ??
  36. RS9268542 (HLA-DQA1) ??
  37. RS9268557 (HLA-DQA1) ??
  38. RS9270965 (HLA-DQA1) ??
  39. RS9270984 (HLA-DQA1) ??
  40. RS9270986 (HLA-DQA1) ??
  41. RS9271100 (HLA-DQA1) ??
  42. RS9271117 (HLA-DQA1) ??
  43. RS9271192 (HLA-DQA1) ??
  44. RS9271209 (HLA-DQA1) ??
  45. RS9271348 (HLA-DQA1) ??
  46. RS9271366 (HLA-DQA1) ??
  47. RS9271588 (HLA-DQA1) ??
  48. RS9271640 (HLA-DQA1) ??
  49. RS9271858 (HLA-DQA1) ??
  50. RS9272105 (HLA-DQA1) ??
  51. RS9272143 (HLA-DQA1) ??
  52. RS9272219 (HLA-DQA1) ??
  53. RS9272346 (HLA-DQA1) ??
  54. RS9272535 (HLA-DQA1) ??
  55. RS9273076 (HLA-DQA1) ??
  56. RS9273349 (HLA-DQA1) ??
  57. RS9273363 (HLA-DQA1) ??
  58. RS9273373 (HLA-DQA1) ??
  59. RS928815 (HLA-DQA1) ??
  60. RS9461776 (HLA-DQA1) ??

Top Gene-Substance Interactions

HLA-DQA1 Interacts with These Diseases

Disease Score

Substances That Increase HLA-DQA1

Substances Interaction Organism Category

Substances That Decrease HLA-DQA1

Substances Interaction Organism Category

Advanced Summary

At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02. The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02. The DQ2 and DQ8 haplotypes, which may occur separately or together, seem to increase the risk of an inappropriate immune response to the protein gluten, which is found in wheat, rye, and barley. This immune system malfunction results in the damage to the body's organs and tissues that occurs in celiac disease. However, the DQ2 and DQ8 haplotypes are also found in 30 percent of the general population, and only 3 percent of individuals with these haplotypes develop celiac disease. idiopathic inflammatory myopathy Genetics Home Reference provides information about idiopathic inflammatory myopathy. juvenile idiopathic arthritis Genetics Home Reference provides information about juvenile idiopathic arthritis. narcolepsy Genetics Home Reference provides information about narcolepsy. type 1 diabetes Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. Type 1 diabetes is characterized by high blood sugar levels resulting from a shortage of the hormone insulin and is caused by autoimmune damage to insulin-producing cells in the pancreas. Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1. One haplotype, written as DRB1*03:01-DQA1*05:01-DQB1*02, is called DR3. The other haplotype, written as DRB1*04:01/02/04/05/08-DQA1*03:01-DQB1*02, is called DR4. People at highest risk of developing type 1 diabetes have one copy of the DR3 haplotype and one copy of the DR4 haplotype in each cell. Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. Variations in other genes and environmental factors are also thought to affect the risk of this complex disorder. autoimmune disorders Certain normal variations of the HLA-DQA1 gene have been associated with increased risk of autoimmune disorders, which occur when the immune system malfunctions and attacks the body's own tissues and organs. It is unclear how different versions of the HLA-DQA1 gene influence the risk of developing autoimmune disorders. These conditions are thought to result from a combination of multiple environmental and genetic factors. Changes in other HLA and non-HLA genes, some of which remain unknown, also likely contribute to the risk of developing these complex conditions. other disorders Normal variations in the HLA-DQA1 gene can affect the body's ability to recognize and react to foreign invaders (pathogens). For example, variations of this gene have been shown to increase or decrease a person's chance of getting infections such as hepatitis B and leprosy or may affect the severity of illness if infection occurs. A particular variant of the HLA-DQA1 gene known as HLA-DQA1*02:01 increases the risk of liver damage in women with advanced breast cancer treated with a drug called lapatinib. Researchers suggest that the variant may increase immune system sensitivity to the drug, resulting in inflammation that damages the liver.

The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. MHC class II genes provide instructions for making proteins that are present on the surface of certain immune system cells. These proteins attach to protein fragments (peptides) outside the cell. MHC class II proteins display these peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it triggers a response to attack the invading viruses or bacteria. The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1. Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. This complex displays foreign peptides to the immune system to trigger the body's immune response. Each MHC class II gene has many possible variations, allowing the immune system to react to a wide range of foreign invaders. Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Myc
  • STAT1
  • STAT1beta
  • STAT1alpha
  • c-Rel

Gene Pathways:

  • Rheumatoid arthritis
  • Immune System
  • Staphylococcus aureus infection
  • Tuberculosis
  • Toxoplasmosis
  • Systemic lupus erythematosus
  • Leishmaniasis
  • Intestinal immune network for IgA production
  • Allograft rejection
  • Cell adhesion molecules (CAMs)
  • Type I diabetes mellitus
  • Graft-versus-host disease
  • Autoimmune thyroid disease
  • Phagosome
  • Viral myocarditis
  • Antigen processing and presentation
  • Asthma

Molecular Function:

  • Mhc Class Ii Receptor Activity
  • Peptide Antigen Binding

Biological Processes:

  • Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii
  • Immune Response
  • Interferon-Gamma-Mediated Signaling Pathway
  • T Cell Costimulation
  • T Cell Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| hla-dqa1| CELIAC1| DC-1 alpha chain| DC-alpha| DQ-A1| HLA class II histocompatibility antigen, DQ alpha 1 chain| HLA-DCA| HLA-DQA| major histocompatibility complex, class II, DQ alpha 1-like| Mamu-DQA| MHC class II antigen| MHC class II DQA1| MHC class II HLA-DQ-alpha-1| MHC HLA-DQ alpha

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved