The Function of HIVEP2
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
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Protein names
Recommended name:
Transcription factor HIVEP2Short name:
MBP-2Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 2HIV-EP2
MHC-binding protein 2
- RS12211360 (HIVEP2) ??
- RS197480 (HIVEP2) ??
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Top Gene-Substance Interactions
HIVEP2 Interacts with These Diseases
| Disease | Score |
Substances That Increase HIVEP2
| Substances | Interaction | Organism | Category |
Substances That Decrease HIVEP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain and skeletal muscle.
Induction:
By mitogens and phorbol ester.
Molecular Function:
- Dna Binding
- Metal Ion Binding
- Sequence-Specific Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Multicellular Organism Development
- Regulation Of Transcription, Dna-Templated
- Signal Transduction
- Transcription From Rna Polymerase Ii Promoter