The Function of HIST1H4A
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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Top Gene-Substance Interactions
Substances That Increase HIST1H4A
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Substances That Decrease HIST1H4A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Chromatin Silencing At Rdna
- Double-Strand Break Repair Via Nonhomologous End Joining
- Nucleosome Assembly
- Dna Replication-Dependent Nucleosome Assembly
- Dna Replication-Independent Nucleosome Assembly
- Dna-Templated Transcription, Initiation
- Telomere Capping
- Gene Silencing By Rna
- Telomere Organization
- Cenp-A Containing Nucleosome Assembly
- Cellular Protein Metabolic Process
- Negative Regulation Of Megakaryocyte Differentiation
- Negative Regulation Of Gene Expression, Epigenetic
- Positive Regulation Of Gene Expression, Epigenetic
- Protein Heterotetramerization
- Beta-Catenin-Tcf Complex Assembly