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  3. HIST1H4A

HIST1H4A (Histone cluster 1 H4 family member a)

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The Function of HIST1H4A

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

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Top Gene-Substance Interactions

Substances That Increase HIST1H4A

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Substances That Decrease HIST1H4A

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Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

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Technical

The following transcription factors affect gene expression:

  • AhR
  • Arnt
  • Pbx1a
  • TBP
  • E2F-4
  • Gfi-1

Molecular Function:

  • Dna Binding
  • Histone Binding
  • Poly(A) Rna Binding
  • Protein Domain Specific Binding

Biological Processes:

  • Beta-Catenin-Tcf Complex Assembly
  • Cellular Protein Metabolic Process
  • Cenp-A Containing Nucleosome Assembly
  • Chromatin Silencing At Rdna
  • Dna Replication-Dependent Nucleosome Assembly
  • Dna Replication-Independent Nucleosome Assembly
  • Dna-Templated Transcription, Initiation
  • Double-Strand Break Repair Via Nonhomologous End Joining
  • Gene Silencing By Rna
  • Negative Regulation Of Gene Expression, Epigenetic
  • Negative Regulation Of Megakaryocyte Differentiation
  • Nucleosome Assembly
  • Positive Regulation Of Gene Expression, Epigenetic
  • Protein Heterotetramerization
  • Telomere Capping
  • Telomere Organization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

H4FA| H4 histone family, member A| HIST1H46L3| histone 1, H4a| histone cluster 1, H4a| histone cluster 1, H4-IV, germinal H4-like 3 (similar to human histone cluster 1, class H4 genes)| histone H4| histone H4-VIII| hist1h4a

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