Summary of HIP1
This gene encodes a membrane protein that helps with endocytosis and protein trafficking in the cells. It is associated with prostate cancer (R).
The Function of HIP1
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Protein names
Recommended name:
Huntingtin-interacting protein 1Short name:
HIP-1Alternative name(s):
Huntingtin-interacting protein IHIP-I
- RS1167796 (HIP1) ??
- RS1167827 (HIP1) ??
- RS1179624 (HIP1) ??
- RS237238 (HIP1) ??
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Top Gene-Substance Interactions
HIP1 Interacts with These Diseases
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Substances That Increase HIP1
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Substances That Decrease HIP1
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Malignant tumor of prostateFrom UniProt: A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).
From NCBI Gene: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] From UniProt: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
Gene Pathways:
Molecular Function:
- Epidermal Growth Factor Receptor Binding
- Structural Constituent Of Cytoskeleton
- Clathrin Binding
- Clathrin Light Chain Binding
- Phosphatidylinositol-3-Phosphate Binding
- Phosphatidylinositol Binding
- Glutamate Receptor Binding
- Ap-2 Adaptor Complex Binding
- Clathrin Adaptor Activity
- Protein Homodimerization Activity
- Phosphatidylinositol-3,4-Bisphosphate Binding
- Protein Heterodimerization Activity
- Actin Filament Binding
- Phosphatidylinositol-3,5-Bisphosphate Binding
Biological Processes:
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Apoptotic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Regulation Of Endocytosis
- Cell Differentiation
- Regulation Of Apoptotic Process
- Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Receptor-Mediated Endocytosis
- Clathrin Coat Assembly
- Protein Stabilization
- Positive Regulation Of Protein Kinase B Signaling
- Clathrin-Dependent Endocytosis
- Apoptotic Signaling Pathway
- Neurotransmitter Receptor Transport
- Positive Regulation Of Platelet-Derived Growth Factor Receptor-Beta Signaling Pathway