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  3. HIP1

HIP1 (Huntingtin interacting protein 1)

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Summary of HIP1

This gene encodes a membrane protein that helps with endocytosis and protein trafficking in the cells. It is associated with prostate cancer (R).

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The Function of HIP1

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Protein names

Recommended name:

Huntingtin-interacting protein 1

Short name:

HIP-1

Alternative name(s):

Huntingtin-interacting protein I
HIP-I

HIP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1167796 (HIP1) ??
  2. RS1167827 (HIP1) ??
  3. RS1179624 (HIP1) ??
  4. RS237238 (HIP1) ??

Top Gene-Substance Interactions

HIP1 Interacts with These Diseases

Disease Score

Substances That Increase HIP1

Substances Interaction Organism Category

Substances That Decrease HIP1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Malignant tumor of prostateFrom UniProt: A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).

     From NCBI Gene: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] From UniProt: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.

Gene Pathways:

  • Huntington's disease

Molecular Function:

  • Actin Filament Binding
  • Ap-2 Adaptor Complex Binding
  • Clathrin Adaptor Activity
  • Clathrin Binding
  • Clathrin Light Chain Binding
  • Epidermal Growth Factor Receptor Binding
  • Glutamate Receptor Binding
  • Phosphatidylinositol-3,4-Bisphosphate Binding
  • Phosphatidylinositol-3,5-Bisphosphate Binding
  • Phosphatidylinositol-3-Phosphate Binding
  • Phosphatidylinositol Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Structural Constituent Of Cytoskeleton

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Apoptotic Process
  • Apoptotic Signaling Pathway
  • Cell Differentiation
  • Clathrin Coat Assembly
  • Clathrin-Dependent Endocytosis
  • Neurotransmitter Receptor Transport
  • Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Platelet-Derived Growth Factor Receptor-Beta Signaling Pathway
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Receptor-Mediated Endocytosis
  • Protein Stabilization
  • Regulation Of Apoptotic Process
  • Regulation Of Endocytosis
  • Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_05251| CG10971 gene product from transcript CG10971-RA| CG10971-PA| CG10971-PB| D623_10014259| Dmel_CG10971| fb98d04| hip-1| Hip1-PA| Hip1-PB| Hip1R| HIP-I| huntingtin-interacting protein 1| huntingtin-interacting protein I| ILWEQ| M91_01051| M959_11289| N300_07244| N302_02618| N303_13039| N309_09946| N310_08707| N322_06532| PANDA_012664| SHON| SHONbeta| SHONgamma| TREES_T100021547| UY3_15808| Y1Q_024456| Y956_15282| Z169_00516| hip1

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