The Function of HEYL
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
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Protein names
Recommended name:
Hairy/enhancer-of-split related with YRPW motif-like proteinAlternative name(s):
hHeyLClass B basic helix-loop-helix protein 33
bHLHb33
Hairy-related transcription factor 3
HRT-3
hHRT3
- RS12037222 (HEYL) ??
- RS3916164 (HEYL) ??
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Top Gene-Substance Interactions
Substances That Increase HEYL
| Substances | Interaction | Organism | Category |
Substances That Decrease HEYL
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By activation of the Notch signaling pathway.
Molecular Function:
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Core Promoter Sequence-Specific
- Transcription Factor Activity, Protein Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Rna Polymerase Ii Transcription Corepressor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Corepressor Activity
- Transcription Factor Binding
- Microsatellite Binding
- Protein Heterodimerization Activity
- Af-1 Domain Binding
Biological Processes:
- Outflow Tract Morphogenesis
- Atrioventricular Valve Morphogenesis
- Pulmonary Valve Morphogenesis
- Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
- Endocardial Cushion Morphogenesis
- Cardiac Ventricle Morphogenesis
- Notch Signaling Pathway
- Mesenchymal Cell Development
- Glomerulus Development
- Skeletal Muscle Cell Differentiation
- Positive Regulation Of Neuron Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cardiac Epithelial To Mesenchymal Transition
- Ventricular Septum Morphogenesis
- Negative Regulation Of Androgen Receptor Signaling Pathway
- Cellular Response To Bmp Stimulus
- Proximal Tubule Development
- Negative Regulation Of Androgen Receptor Activity