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  3. HEYL

HEYL (Hes related family bHLH transcription factor with YRPW motif-like)

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The Function of HEYL

Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

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Protein names

Recommended name:

Hairy/enhancer-of-split related with YRPW motif-like protein

Alternative name(s):

hHeyL
Class B basic helix-loop-helix protein 33
bHLHb33
Hairy-related transcription factor 3
HRT-3
hHRT3

HEYL SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12037222 (HEYL) ??
  2. RS3916164 (HEYL) ??

Top Gene-Substance Interactions

Substances That Increase HEYL

Substances Interaction Organism Category

Substances That Decrease HEYL

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Gene Pathways:

  • Disease
  • Signal Transduction

Induction:

By activation of the Notch signaling pathway.

Molecular Function:

  • Af-1 Domain Binding
  • Microsatellite Binding
  • Protein Heterodimerization Activity
  • Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Corepressor Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Protein Binding
  • Transcription Factor Activity, Rna Polymerase Ii Core Promoter Sequence-Specific
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding

Biological Processes:

  • Atrioventricular Valve Morphogenesis
  • Cardiac Epithelial To Mesenchymal Transition
  • Cardiac Ventricle Morphogenesis
  • Cellular Response To Bmp Stimulus
  • Endocardial Cushion Morphogenesis
  • Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
  • Glomerulus Development
  • Mesenchymal Cell Development
  • Negative Regulation Of Androgen Receptor Activity
  • Negative Regulation Of Androgen Receptor Signaling Pathway
  • Negative Regulation Of Transcription, Dna-Templated
  • Notch Signaling Pathway
  • Outflow Tract Morphogenesis
  • Positive Regulation Of Neuron Differentiation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Proximal Tubule Development
  • Pulmonary Valve Morphogenesis
  • Skeletal Muscle Cell Differentiation
  • Ventricular Septum Morphogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_13927| AS28_08619| bHLHb33| CB1_001061004| class B basic helix-loop-helix protein 33| D623_10028954| EGK_00601| EH28_23825| fk74e12| GW7_09808| H920_06072| hairy and enhance of split related 3| hairy and enhancer of split-related protein 3| hairy/enhancer-of-split related with YRPW motif 3| hairy/enhancer-of-split related with YRPW motif-like| hairy/enhancer-of-split related with YRPW motif-like protein| hairy/enhancer-of-split related with YRPW motif-like protein-like| hairy-related transcription factor 3| HESR3| hes-related family bHLH transcription factor with YRPW motif| hes-related family bHLH transcription factor with YRPW motif-like| Hey3| HEY-like protein| hHeyL| hHRT3| HRT3| HRT-3| I79_012214| M91_09935| M959_12776| MDA_GLEAN10001934| mHRT3| N301_15275| N302_13957| N306_00476| N307_14678| N308_02000| N312_09381| N320_05827| N322_07448| N324_08013| N326_06367| N327_03732| N328_08028| N329_08461| N330_08352| N333_07893| N334_01866| N335_10702| N336_12261| N339_06122| N341_05995| PAL_GLEAN10004350| PANDA_020837| TREES_T100000909| UY3_14473| Y1Q_019128| Y956_14950| Z169_00240| heyl

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