The Function of HEXIM1
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
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Protein names
Recommended name:
Protein HEXIM1Alternative name(s):
Cardiac lineage protein 1Estrogen down-regulated gene 1 protein
Hexamethylene bis-acetamide-inducible protein 1
Menage a quatre protein 1
Top Gene-Substance Interactions
Substances That Increase HEXIM1
| Substances | Interaction | Organism | Category |
Substances That Decrease HEXIM1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
Induction:
Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.
Molecular Function:
Biological Processes:
- Heart Development
- Negative Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Signal Transduction By P53 Class Mediator
- Transcription, Dna-Templated