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  3. HEXIM1

HEXIM1 (Hexamethylene bisacetamide inducible 1)

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The Function of HEXIM1

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

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Protein names

Recommended name:

Protein HEXIM1

Alternative name(s):

Cardiac lineage protein 1
Estrogen down-regulated gene 1 protein
Hexamethylene bis-acetamide-inducible protein 1
Menage a quatre protein 1

Top Gene-Substance Interactions

Substances That Increase HEXIM1

Substances Interaction Organism Category

Substances That Decrease HEXIM1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • Nkx2-5
  • C/EBPalpha

Tissue specificity:

Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.

Induction:

Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.

Molecular Function:

  • 7sk Snrna Binding
  • Cyclin-Dependent Protein Serine/Threonine Kinase Inhibitor Activity
  • Snrna Binding

Biological Processes:

  • Heart Development
  • Negative Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Signal Transduction By P53 Class Mediator
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CLP1| cardiac lineage protein 1| CB1_000085016| Clp-1| D623_10009516| EDG1| EGK_08827| estrogen down-regulated gene 1 protein| fd44h02| hexamethylene bis-acetamide inducible 1| hexamethylene bisacetamide-inducible protein| hexamethylene bis-acetamide-inducible protein 1| hexamethylene-bis-acetamide-inducible transcript 1| hexamthylene bis-acetamide inducible 1| hexim| HIS1| HMBA-inducible| HMBA-inducible 1| MAQ1| menage a quatre 1| menage a quatre protein 1| N307_10478| PAL_GLEAN10004269| PANDA_008477| protein HEXIM| protein HEXIM1| protein HEXIM1-like protein| TREES_T100006011| UY3_01336| hexim1

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