The Function of HERC5
Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
Protein names
Recommended name:
E3 ISG15--protein ligase HERC5Alternative name(s):
Cyclin-E-binding protein 1HECT domain and RCC1-like domain-containing protein 5
- RS10516809 (HERC5) ??
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Top Gene-Substance Interactions
Substances That Increase HERC5
| Substances | Interaction | Organism | Category |
Substances That Decrease HERC5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
Gene Pathways:
Induction:
By IFNB1/IFN-beta. In endothelial cells, by TNF, IL1B/interleukin-1B and by bacterial lipopolysaccharides (LPS), hardly induced in other cells of the vascular wall such as primary smooth muscle cells and fibroblasts. By viral infection.
Caution:
Was thought to be a ubiquitin ligase ubiquitinated by UBE2D1, but was confirmed by numerous studies that it's main function is as E3 ISG15 ligase.
Molecular Function:
- Isg15 Transferase Activity
- Poly(A) Rna Binding
- Ubiquitin-Protein Transferase Activity
- Ligase Activity
Biological Processes:
- Defense Response To Virus
- Innate Immune Response
- Isg15-Protein Conjugation
- Negative Regulation Of Type I Interferon Production
- Protein Polyubiquitination
- Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
- Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Regulation Of Defense Response To Virus