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  3. HERC5

HERC5 (HECT and RLD domain containing E3 ubiquitin protein ligase 5)

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The Function of HERC5

Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.

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Protein names

Recommended name:

E3 ISG15--protein ligase HERC5

Alternative name(s):

Cyclin-E-binding protein 1
HECT domain and RCC1-like domain-containing protein 5

HERC5 SNPs

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  1. RS10516809 (HERC5) ??

Top Gene-Substance Interactions

Substances That Increase HERC5

Substances Interaction Organism Category

Substances That Decrease HERC5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.

Gene Pathways:

  • Immune System

Induction:

By IFNB1/IFN-beta. In endothelial cells, by TNF, IL1B/interleukin-1B and by bacterial lipopolysaccharides (LPS), hardly induced in other cells of the vascular wall such as primary smooth muscle cells and fibroblasts. By viral infection.

Caution:

Was thought to be a ubiquitin ligase ubiquitinated by UBE2D1, but was confirmed by numerous studies that it's main function is as E3 ISG15 ligase.

Molecular Function:

  • Isg15 Transferase Activity
  • Poly(A) Rna Binding
  • Ubiquitin-Protein Transferase Activity
  • Ligase Activity

Biological Processes:

  • Defense Response To Virus
  • Innate Immune Response
  • Isg15-Protein Conjugation
  • Negative Regulation Of Type I Interferon Production
  • Protein Polyubiquitination
  • Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
  • Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Regulation Of Defense Response To Virus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CEB1| CEBP1| cyclin-E-binding protein 1| D623_10003922| E3 ISG15--protein ligase HERC5| H920_17795| HECT and RLD domain containing E3 ubiquitin protein ligase family member 6| HECT domain and RCC1-like domain-containing protein 5| hect domain and RLD 5| Herc6| M91_13345| PAL_GLEAN10010914| PANDA_001439| probable E3 ubiquitin-protein ligase HERC5| Putative E3 ubiquitin-protein ligase HERC5| Putative E3 ubiquitin-protein ligase HERC6| herc5

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