The Function of HELLS
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
Protein names
Recommended name:
Lymphoid-specific helicaseAlternative name(s):
Proliferation-associated SNF2-like proteinSWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
- RS12772169 (HELLS) ??
- RS12777823 (HELLS) ??
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Top Gene-Substance Interactions
HELLS Interacts with These Diseases
| Disease | Score |
Substances That Increase HELLS
| Substances | Interaction | Organism | Category |
Substances That Decrease HELLS
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
Induction:
By concanavalin-A in peripheral blood leukocytes.
Molecular Function:
Biological Processes:
- Methylation-Dependent Chromatin Silencing
- Transcription, Dna-Templated
- Mitotic Nuclear Division
- Multicellular Organism Development
- Maintenance Of Dna Methylation
- Pericentric Heterochromatin Assembly
- Lymphocyte Proliferation
- Cell Division