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  3. HELLS

HELLS (Helicase, lymphoid-specific)

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The Function of HELLS

Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.

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Protein names

Recommended name:

Lymphoid-specific helicase

Alternative name(s):

Proliferation-associated SNF2-like protein
SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6

HELLS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12772169 (HELLS) ??
  2. RS12777823 (HELLS) ??

Top Gene-Substance Interactions

HELLS Interacts with These Diseases

Disease Score

Substances That Increase HELLS

Substances Interaction Organism Category

Substances That Decrease HELLS

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • MRF-2
  • Brachyury
  • GATA-3
  • NF-AT4
  • NF-AT3
  • NF-AT2

Tissue specificity:

Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.

Induction:

By concanavalin-A in peripheral blood leukocytes.

Molecular Function:

  • Atp Binding
  • Helicase Activity

Biological Processes:

  • Cell Division
  • Lymphocyte Proliferation
  • Maintenance Of Dna Methylation
  • Methylation-Dependent Chromatin Silencing
  • Mitotic Nuclear Division
  • Multicellular Organism Development
  • Pericentric Heterochromatin Assembly
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_02538| AS28_05943| CB1_000155007| EH28_09219| GW7_13556| H920_08654| helicase, lymphoid specific| helicase, lymphoid-specific isoform 3-like protein| ICF4| LSH| Lymphocyte helicase| lymphocyte-specific helicase| lymphoid-specific helicase| lymphoid-specific helicase isoform 5-like| lymphoid-specific helicase isoform-like| Lymphoid-specific helicase-like protein| Lysh| M959_03560| MDA_GLEAN10014825| N300_11792| N301_10711| N302_13422| N303_09624| N305_02696| N306_10564| N307_06077| N308_00267| N309_02646| N310_01357| N311_12548| N312_10783| N320_12306| N321_00541| N322_07304| N325_06809| N326_03812| N328_09302| N329_03829| N334_10811| N335_04715| N336_07571| N341_01693| Nbla10143| PAL_GLEAN10018341| PASG| proliferation-associated SNF2-like protein| smarca6| SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6| Tbc1d12| TBC1D12: TBC1 domain family, member 12| TREES_T100006512| UY3_00783| Y1Q_018585| Y956_09078| YFK8| hells

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