Summary of HDAC1
This gene encodes a protein that regulates eukaryotic gene expression. It also helps control cell proliferation and differentiation (R).
The Function of HDAC1
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Protein names
Recommended name:
Histone deacetylase 1Short name:
HD1- RS1741981 (HDAC1) ??
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Top Gene-Substance Interactions
HDAC1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HDAC1
| Substances | Interaction | Organism | Category |
Substances That Decrease HDAC1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Gene Pathways:
Molecular Function:
- Transcription Regulatory Region Sequence-Specific Dna Binding
- Core Promoter Binding
- Rna Polymerase Ii Transcription Factor Binding
- Rna Polymerase Ii Repressing Transcription Factor Binding
- Rna Polymerase Ii Transcription Corepressor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Histone Deacetylase Activity
- Transcription Factor Binding
- Deacetylase Activity
- Enzyme Binding
- Nad-Dependent Histone Deacetylase Activity (H3-K14 Specific)
- Protein Deacetylase Activity
- Activating Transcription Factor Binding
- Histone Deacetylase Binding
- Transcription Regulatory Region Dna Binding
- Protein N-Terminus Binding
- Nf-Kappab Binding
- Repressing Transcription Factor Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Chromatin Organization
- Chromatin Remodeling
- Methylation-Dependent Chromatin Silencing
- Transcription, Dna-Templated
- Protein Deacetylation
- Blood Coagulation
- Positive Regulation Of Cell Proliferation
- Epidermal Cell Differentiation
- Negative Regulation Of Gene Expression
- Positive Regulation Of Receptor Biosynthetic Process
- Viral Process
- Histone Deacetylation
- Circadian Regulation Of Gene Expression
- Odontogenesis Of Dentin-Containing Tooth
- Embryonic Digit Morphogenesis
- Atp-Dependent Chromatin Remodeling
- Negative Regulation Of Apoptotic Process
- Negative Regulation By Host Of Viral Transcription
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Androgen Receptor Signaling Pathway
- Hair Follicle Placode Formation
- Eyelid Development In Camera-Type Eye
- Fungiform Papilla Formation
- Histone H3 Deacetylation
- Histone H4 Deacetylation
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Regulation Of Signal Transduction By P53 Class Mediator
- Beta-Catenin-Tcf Complex Assembly