Summary of HBEGF
This gene encodes a protein that helps with muscle cell and heart function (R).
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The Function of HBEGF
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Protein names
Recommended name:
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factorShort name:
DT-RAlternative name(s):
HB-EGFHBEGF
Diphtheria toxin receptor
- RS11168036 (HBEGF) ??
- RS13385 (HBEGF) ??
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Top Gene-Substance Interactions
HBEGF Interacts with These Diseases
| Disease | Score |
Substances That Increase HBEGF
| Substances | Interaction | Organism | Category |
Substances That Decrease HBEGF
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Epidermal Growth Factor Receptor Binding
- Growth Factor Activity
- Heparin Binding
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
Biological Processes:
- Mapk Cascade
- Signal Transduction
- Epidermal Growth Factor Receptor Signaling Pathway
- Muscle Organ Development
- Regulation Of Heart Contraction
- Positive Regulation Of Cell Proliferation
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Migration
- Wound Healing, Spreading Of Epidermal Cells
- Erbb2 Signaling Pathway
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Negative Regulation Of Elastin Biosynthetic Process
- Positive Regulation Of Keratinocyte Migration
- Positive Regulation Of Protein Kinase B Signaling
- Cell Chemotaxis
- Positive Regulation Of Wound Healing
- Regulation Of Cell Motility