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  3. HBEGF

HBEGF (Heparin binding EGF like growth factor)

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Summary of HBEGF

This gene encodes a protein that helps with muscle cell and heart function (R).

0 users want this gene increased, 0 users want it decreased

The Function of HBEGF

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Protein names

Recommended name:

Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

Short name:

DT-R

Alternative name(s):

HB-EGF
HBEGF
Diphtheria toxin receptor

HBEGF SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11168036 (HBEGF) ??
  2. RS13385 (HBEGF) ??

Top Gene-Substance Interactions

HBEGF Interacts with These Diseases

Disease Score

Substances That Increase HBEGF

Substances Interaction Organism Category

Substances That Decrease HBEGF

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • Fra-1

Gene Pathways:

  • Disease
  • Immune System
  • Signal Transduction
  • Epithelial cell signaling in Helicobacter pylori infection
  • GnRH signaling pathway

Molecular Function:

  • Epidermal Growth Factor Receptor Binding
  • Growth Factor Activity
  • Heparin Binding
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Cell Chemotaxis
  • Epidermal Growth Factor Receptor Signaling Pathway
  • Erbb2 Signaling Pathway
  • Mapk Cascade
  • Muscle Organ Development
  • Negative Regulation Of Elastin Biosynthetic Process
  • Phosphatidylinositol-Mediated Signaling
  • Positive Regulation Of Cell Growth
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Keratinocyte Migration
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Wound Healing
  • Regulation Of Cell Motility
  • Regulation Of Heart Contraction
  • Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Signal Transduction
  • Wound Healing, Spreading Of Epidermal Cells
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14652| AS27_04340| AS28_11680| CB1_000072021| D623_10027824| diphtheria toxin receptor| diphtheria toxin receptor (heparin-binding EGF-like growth factor)| diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)| Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)| DTR| DTS| DTSF| GFHB| GW7_08876| HB-EGF| Hegfl| heparin-binding EGF-like growth factor| heparin-binding epidermal -growth factor| heparin-binding epidermal growth factor| heparin binding epidermal growth factor-like growth factor| heparin-binding epidermal growth factor-like growth factor| heparin-binding epidermal -growth - like growth factor| M959_04114| MDA_GLEAN10012442| N300_08127| N301_15732| N302_09870| N303_04336| N305_08933| N306_09045| N307_02070| N308_07794| N309_12289| N310_10494| N311_08806| N312_09561| N321_08287| N322_07127| N324_11816| N325_09018| N326_06325| N327_06305| N328_04173| N330_07828| N331_09991| N332_07732| N333_09055| N334_08298| N335_10002| N336_08245| N339_06881| N340_09629| N341_04609| PAL_GLEAN10016791| PANDA_000375| Proheparin-binding EGF-like growth factor| TREES_T100019628| UY3_06459| Y1Q_015578| Y956_11686| Z169_14515| hbegf

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