Summary of HAPLN1
The gene codes for a protein, hyaluronan and proteoglycan link protein 1. It is on chromosome 5 [R].
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The Function of HAPLN1
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Protein names
Recommended name:
Hyaluronan and proteoglycan link protein 1Alternative name(s):
Cartilage-linking protein 1Cartilage-link protein
Proteoglycan link protein
- RS310501 (HAPLN1) ??
- RS3846635 (HAPLN1) ??
- RS4466137 (HAPLN1) ??
- RS4552569 (HAPLN1) ??
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Top Gene-Substance Interactions
HAPLN1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HAPLN1
| Substances | Interaction | Organism | Category |
Substances That Decrease HAPLN1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Weakly expressed in the brain.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cell Adhesion
- Central Nervous System Development
- Extracellular Matrix Organization
- Skeletal System Development
- Mitophagy In Response To Mitochondrial Depolarization