The Function of HAO1
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
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Protein names
Recommended name:
Hydroxyacid oxidase 1Short name:
GOXAlternative name(s):
HAOX1Glycolate oxidase
Top Gene-Substance Interactions
HAO1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HAO1
| Substances | Interaction | Organism | Category |
Substances That Decrease HAO1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver.
Molecular Function:
- (S)-2-Hydroxy-Acid Oxidase Activity
- Receptor Binding
- Glycolate Oxidase Activity
- Fmn Binding
- Glyoxylate Oxidase Activity
- Very-Long-Chain-(S)-2-Hydroxy-Acid Oxidase Activity
- Long-Chain-(S)-2-Hydroxy-Long-Chain-Acid Oxidase Activity
- Medium-Chain-(S)-2-Hydroxy-Acid Oxidase Activity
Biological Processes:
- Fatty Acid Alpha-Oxidation
- Response To Oxidative Stress
- Glycolate Catabolic Process
- Glyoxylate Metabolic Process