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  3. HAO1

HAO1 (Hydroxyacid oxidase 1)

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The Function of HAO1

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

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Protein names

Recommended name:

Hydroxyacid oxidase 1

Short name:

GOX

Alternative name(s):

HAOX1
Glycolate oxidase

Top Gene-Substance Interactions

HAO1 Interacts with These Diseases

Disease Score

Substances That Increase HAO1

Substances Interaction Organism Category

Substances That Decrease HAO1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1

Tissue specificity:

Liver.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Peroxisome
  • Glyoxylate and dicarboxylate metabolism

Molecular Function:

  • (S)-2-Hydroxy-Acid Oxidase Activity
  • Fmn Binding
  • Glycolate Oxidase Activity
  • Glyoxylate Oxidase Activity
  • Long-Chain-(S)-2-Hydroxy-Long-Chain-Acid Oxidase Activity
  • Medium-Chain-(S)-2-Hydroxy-Acid Oxidase Activity
  • Receptor Binding
  • Very-Long-Chain-(S)-2-Hydroxy-Acid Oxidase Activity

Biological Processes:

  • Fatty Acid Alpha-Oxidation
  • Glycolate Catabolic Process
  • Glyoxylate Metabolic Process
  • Response To Oxidative Stress
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_11320| AS28_01675| CB1_000951019| EH28_21187| glycolate oxidase| glycolate oxidase 1| GOX| GOX1| GW7_19599| H920_11174| Hao-1| haox1| hydroxyacid oxidase 1-like protein| hydroxyacid oxidase 1, liver| hydroxyacid oxidase (glycolate oxidase) 1| I79_000442| M959_01221| MDA_GLEAN10025054| N300_06359| N301_10987| N302_14364| N303_01208| N305_05015| N306_06632| N307_05866| N308_11913| N309_08710| N311_01785| N312_12453| N320_10847| N321_06070| N322_06322| N324_09905| N325_11827| N327_07382| N328_11300| N329_04139| N330_14188| N332_06851| N333_01146| N334_11656| N336_11246| N339_13030| N340_07876| PAL_GLEAN10024077| PANDA_016525| (S)-2-hydroxy-acid oxidase| TREES_T100015170| UY3_11116| XDH1| Y1Q_017807| Y956_14535| Z169_07353| hao1

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