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  3. HAL

HAL (Histidine ammonia-lyase)

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Summary of HAL

This gene encodes an enzyme called histadase that breaks down the amino acid histidine, a building block of most proteins. Mutations can cause the inability to break down histadine, but there are not reported health problems (R).

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Protein names

Recommended name:

Histidine ammonia-lyase

Alternative name(s):

Histidase

HAL SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7297245 (HAL) ??

Top Gene-Substance Interactions

Substances That Increase HAL

Substances Interaction Organism Category

Substances That Decrease HAL

Substances Interaction Organism Category

Advanced Summary

     histidinemia At least four mutations in the HAL gene have been found to cause histidinemia. All of these mutations change single amino acids in the histidase enzyme. These mutations are thought to decrease or eliminate enzyme activity, resulting in an inability to break down histidine. Histidine that is not broken down accumulates in the blood, but it typically causes no health problems.

     The HAL gene provides instructions for making an enzyme called histidase. Histidase breaks down the amino acid histidine, a building block of most proteins. Histidase is active (expressed) primarily in the liver and the skin. This enzyme breaks down histidine to a molecule called urocanic acid. In the liver, urocanic acid is broken down to form another amino acid called glutamic acid. In the skin, urocanic acid is involved in the response to ultraviolet (UV) light.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • Nkx2-5
  • PPAR-alpha
  • NF-1

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Nitrogen metabolism
  • Histidine metabolism

Molecular Function:

  • Histidine Ammonia-Lyase Activity

Biological Processes:

  • Histidine Catabolic Process
  • Histidine Catabolic Process To Glutamate And Formamide
  • Histidine Catabolic Process To Glutamate And Formate

Drug Bank:

  • L-Histidine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

A306_11407| Anapl_11146| AS27_09640| AS28_05586| CB1_000994008| D623_10025595| H920_07441| his| histidase| histidine ammonia lyase| Hsd| HSTD| M959_11178| MDA_GLEAN10016078| N300_06669| N301_14710| N302_12864| N303_04490| N305_08162| N306_04236| N308_05440| N309_05557| N310_13341| N311_11250| N312_07579| N320_05314| N321_06432| N322_11398| N324_04684| N326_11814| N327_03472| N328_12439| N329_07911| N331_06576| N332_10834| N333_08768| N334_04661| N335_03155| N339_08540| N340_08531| N341_02411| PAL_GLEAN10015522| TREES_T100009224| UY3_15993| Y956_04061| Z169_09273| hal

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