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  3. HABP2

HABP2 (Hyaluronan binding protein 2)

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Summary of HABP2

This gene encodes a protein that works as a tumor suppressor (R).

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The Function of HABP2

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).

Protein names

Recommended name:

Hyaluronan-binding protein 2

Short name:

FSAP

Alternative name(s):

Factor VII-activating protease
Factor seven-activating protease
Hepatocyte growth factor activator-like protein
Plasma hyaluronan-binding protein

HABP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7080536 (HABP2) ??

Top Gene-Substance Interactions

Substances That Increase HABP2

Substances Interaction Organism Category

Substances That Decrease HABP2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: ThrombophiliaThyroid cancer, nonmedullary, 5From UniProt: Thyroid cancer, non-medullary, 5 (NMTC5): A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. [MIM:616535]

     From NCBI Gene: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] From UniProt: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB

Tissue specificity:

Ubiquitously expressed.

Molecular Function:

  • Calcium Ion Binding
  • Glycosaminoglycan Binding
  • Serine-Type Endopeptidase Activity

Biological Processes:

  • Cell Adhesion

Drug Bank:

  • Hyaluronic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_06825| AS27_02772| AS28_09772| CB1_000678034| D623_10027933| factor seven-activating protease| factor VII-activating protease| factor VII activating protein| fd56a04| FSAP| H920_09632| Habp| habp2-prov protein| hepatocyte growth factor activator-like protein| HGFAL| hyaduronic acid-binding protein 2| Hyaluronan-binding protein 2| hyaluronan-binding protein 2-like protein| hyaluronic acid binding protein 2| I79_025534| M91_09908| M959_11511| N300_04611| N301_07046| N302_14614| N303_05181| N305_10794| N306_13969| N307_08844| N308_15749| N309_04827| N310_08043| N311_13198| N312_10512| N320_10235| N321_09256| N322_04723| N324_05828| N325_12144| N326_11865| N328_08749| N329_09303| N330_06741| N331_05544| N332_11082| N333_12615| N334_03870| N335_03861| N336_09072| N339_11383| N340_00717| N341_12836| NMTC5| PAL_GLEAN10014176| PANDA_001413| Phbp| plasma hyaluronan binding protein| plasma hyaluronan-binding protein| TREES_T100003498| trypsin I-P1| UY3_03763| Y1Q_021935| Y956_01365| Z169_06312| habp2

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