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  3. H2AFX

H2AFX (H2A histone family member X)

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Summary of H2AFX

This gene encodes a protein that is needed for DNA formation (R).

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The Function of H2AFX

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Protein names

Recommended name:

Histone H2AX

Alternative name(s):

H2a/x
Histone H2A.X

H2AFX SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2509049 (H2AFX) ??

Top Gene-Substance Interactions

H2AFX Interacts with These Diseases

Disease Score

Substances That Increase H2AFX

Substances Interaction Organism Category

Substances That Decrease H2AFX

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AP-1
  • c-Jun
  • YY1
  • GATA-3

Gene Pathways:

  • Disease
  • Signal Transduction
  • Gene Expression
  • Cellular responses to stress
  • Mus musculus biological processes
  • DNA Repair
  • Chromatin organization
  • Systemic lupus erythematosus

Developmental stage:

Synthesized in G1 as well as in S-phase.

Molecular Function:

  • Damaged Dna Binding
  • Dna Binding
  • Enzyme Binding
  • Histone Binding

Biological Processes:

  • Cellular Response To Dna Damage Stimulus
  • Cellular Response To Gamma Radiation
  • Cellular Senescence
  • Cerebral Cortex Development
  • Chromatin Silencing
  • Dna Damage Checkpoint
  • Double-Strand Break Repair
  • Double-Strand Break Repair Via Homologous Recombination
  • Double-Strand Break Repair Via Nonhomologous End Joining
  • Meiotic Cell Cycle
  • Nucleosome Assembly
  • Positive Regulation Of Dna Repair
  • Response To Ionizing Radiation
  • Spermatogenesis
  • Viral Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| EGK_06977| gammaH2ax| H2A histone family, member X| H2a/x| H2AX| H2A.X| H2AX histone| hist1h2ab| Hist5-2ax| histone 1, H2ab| histone 5 protein 2ax| histone H2A.x| histone H2AX| RGD1566119| h2afx

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