Summary of H2AFX
This gene encodes a protein that is needed for DNA formation (R).
The Function of H2AFX
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Protein names
Recommended name:
Histone H2AXAlternative name(s):
H2a/xHistone H2A.X
- RS2509049 (H2AFX) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
H2AFX Interacts with These Diseases
Disease | Score |
Substances That Increase H2AFX
Substances | Interaction | Organism | Category |
Substances That Decrease H2AFX
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Developmental stage:
Synthesized in G1 as well as in S-phase.
Molecular Function:
Biological Processes:
- Cellular Response To Dna Damage Stimulus
- Cellular Response To Gamma Radiation
- Cellular Senescence
- Cerebral Cortex Development
- Chromatin Silencing
- Dna Damage Checkpoint
- Double-Strand Break Repair
- Double-Strand Break Repair Via Homologous Recombination
- Double-Strand Break Repair Via Nonhomologous End Joining
- Meiotic Cell Cycle
- Nucleosome Assembly
- Positive Regulation Of Dna Repair
- Response To Ionizing Radiation
- Spermatogenesis
- Viral Process