Summary of H2AFX
This gene encodes a protein that is needed for DNA formation (R).
The Function of H2AFX
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Protein names
Recommended name:
Histone H2AXAlternative name(s):
H2a/xHistone H2A.X
- RS2509049 (H2AFX) ??
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Top Gene-Substance Interactions
H2AFX Interacts with These Diseases
| Disease | Score |
Substances That Increase H2AFX
| Substances | Interaction | Organism | Category |
Substances That Decrease H2AFX
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Developmental stage:
Synthesized in G1 as well as in S-phase.
Molecular Function:
Biological Processes:
- Dna Damage Checkpoint
- Double-Strand Break Repair Via Homologous Recombination
- Double-Strand Break Repair
- Double-Strand Break Repair Via Nonhomologous End Joining
- Nucleosome Assembly
- Chromatin Silencing
- Cellular Response To Dna Damage Stimulus
- Spermatogenesis
- Response To Ionizing Radiation
- Viral Process
- Cerebral Cortex Development
- Positive Regulation Of Dna Repair
- Meiotic Cell Cycle
- Cellular Response To Gamma Radiation
- Cellular Senescence