Summary of GZMB
This gene encodes a protein that helps with programmed cell death in the immune system resposne (R).
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The Function of GZMB
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Protein names
Recommended name:
Granzyme BShort name:
C11Alternative name(s):
CTLA-1Cathepsin G-like 1
CTSGL1
Cytotoxic T-lymphocyte proteinase 2
Lymphocyte protease
Fragmentin-2
Granzyme-2
Human lymphocyte protein
HLP
SECT
T-cell serine protease 1-3E
- RS7144366 (GZMB) ??
- RS8192917 (GZMB) ??
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Top Gene-Substance Interactions
GZMB Interacts with These Diseases
| Disease | Score |
Substances That Increase GZMB
| Substances | Interaction | Organism | Category |
Substances That Decrease GZMB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.
Enzyme Regulation:
Inactivated by the serine protease inhibitor diisopropylfluorophosphate.
Molecular Function:
Biological Processes:
- Apoptotic Process
- Protein Processing
- Cytolysis
- Natural Killer Cell Mediated Cytotoxicity
- Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway