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  3. GZMB

GZMB (Granzyme B)

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Summary of GZMB

This gene encodes a protein that helps with programmed cell death in the immune system resposne (R).

0 users want this gene increased, 0 users want it decreased

The Function of GZMB

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Protein names

Recommended name:

Granzyme B

Short name:

C11

Alternative name(s):

CTLA-1
Cathepsin G-like 1
CTSGL1
Cytotoxic T-lymphocyte proteinase 2
Lymphocyte protease
Fragmentin-2
Granzyme-2
Human lymphocyte protein
HLP
SECT
T-cell serine protease 1-3E

GZMB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7144366 (GZMB) ??
  2. RS8192917 (GZMB) ??

Top Gene-Substance Interactions

GZMB Interacts with These Diseases

Disease Score

Substances That Increase GZMB

Substances Interaction Organism Category

Substances That Decrease GZMB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • STAT5A
  • AML1a
  • c-Rel

Gene Pathways:

  • Signal Transduction
  • Autoimmune thyroid disease
  • Natural killer cell mediated cytotoxicity
  • Apoptosis
  • Allograft rejection
  • Graft-versus-host disease
  • Type I diabetes mellitus

Induction:

By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.

Enzyme Regulation:

Inactivated by the serine protease inhibitor diisopropylfluorophosphate.

Molecular Function:

  • Serine-Type Endopeptidase Activity
  • Serine-Type Peptidase Activity

Biological Processes:

  • Apoptotic Process
  • Cytolysis
  • Natural Killer Cell Mediated Cytotoxicity
  • Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
  • Protein Processing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

C11| HLP| GLP-1| BDMD1| cathepsin G-like 1| CCP1| CCP-1/C11| CCPI| CGL1| CGL-1| CSPB| CSP-B| Ctla1| Ctla-1| CTSGL1| cytotoxic cell protease 1| cytotoxic serine protease B| cytotoxic T-lymphocyte proteinase 2| duodenase-1| duodenase I| duodenum serine protease| fragmentin| fragmentin 2| fragmentin-2| GLP I| GLP III| granzyme B(G,H)| granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)| granzyme H| granzyme-like protein 1| granzyme-like protein I| GRB| GZB| GZMH| human lymphocyte protein| natural killer cell protease 1| RNKP-1| SECT| T-cell serine protease 1-3E| gzmb

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