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  3. GUCY1A3

GUCY1A3 (Guanylate cyclase 1 soluble subunit alpha)

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Protein names

Recommended name:

Guanylate cyclase soluble subunit alpha-3

Alternative name(s):

GCS-alpha-3
GCS-alpha-1
Soluble guanylate cyclase large subunit

GUCY1A3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10019835 (GUCY1A3) ??
  2. RS13139571 (GUCY1A3) ??
  3. RS13143871 (GUCY1A3) ??
  4. RS1483035 (GUCY1A3) ??
  5. RS1842896 (GUCY1A3) ??
  6. RS72689147 (GUCY1A3) ??

Top Gene-Substance Interactions

GUCY1A3 Interacts with These Diseases

Disease Score

Substances That Increase GUCY1A3

Substances Interaction Organism Category

Substances That Decrease GUCY1A3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Detected in brain cortex and lung (at protein level).

Gene Pathways:

  • Hemostasis
  • Vascular smooth muscle contraction
  • Purine metabolism
  • Long-term depression
  • Salivary secretion

Enzyme Regulation:

Activated by nitric oxide in the presence of magnesium or manganese ions.

Cofactor:

Has also activity with Mn(2+) (in vitro).

Molecular Function:

  • Gtp Binding
  • Guanylate Cyclase Activity
  • Heme Binding
  • Receptor Activity
  • Ion Binding

Biological Processes:

  • Blood Circulation
  • Cgmp Biosynthetic Process
  • Nitric Oxide Mediated Signal Transduction
  • Positive Regulation Of Cgmp Biosynthetic Process
  • Regulation Of Blood Pressure
  • Relaxation Of Vascular Smooth Muscle
  • Response To Defense-Related Host Nitric Oxide Production
  • Response To Herbicide
  • Response To Organic Cyclic Compound
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| guanylate cyclase 1, soluble, alpha 2| alpha 1 sGC| Anapl_04136| AS27_12847| AS28_13280| frgcs-alpha1| GC-SA3| GC-S-alpha-1| GCS-alpha-1| GCS-alpha-3| guanylate cyclase 1, soluble, alpha 3| guanylate cyclase 1 soluble subunit alpha 3| Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase)| guanylate cyclase soluble subunit alpha-1| guanylate cyclase soluble subunit alpha-3| GUC1A3| GUCA3| GUCSA3| GUCY1A1| GUCY1A2| GW7_04528| H920_06904| larger subunit of soluble guanylyl cyclase| M959_02810| MDA_GLEAN10015548| MYMY6| N301_13193| N302_04326| N303_14657| N305_00480| N306_02786| N307_03817| N308_08149| N309_12654| N310_07585| N311_09148| N312_00475| N320_05937| N321_06003| N324_05998| N325_00650| N327_09028| N328_10115| N329_08248| N330_09882| N332_02430| N333_08666| N334_09476| N335_01944| N339_04942| N340_08619| nitric oxide-sensitive guanylyl cyclase alpha 1 subunit| NO-sensitive GC alpha 1 subunit| PAL_GLEAN10012354| PANDA_013696| SGC| sgc1a1| sGC-alpha1| soluble guanylate cyclase 1 alpha 3| soluble guanylate cyclase large subunit| soluble guanylate cyclase large subunit alpha 1| soluble guanylyl cyclase alpha1 subunit| soluble guanylyl cyclase alpha subunit| TREES_T100002213| Y1Q_000904| Y956_01045| gucy1a3

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