Summary of GSTT1
GSTT1 is a theta class glutathione S-transferase . This enzyme has been claimed to have an important role in human carcinogenesis.
The Function of GSTT1
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Protein names
Recommended name:
Glutathione S-transferase theta-1Alternative name(s):
GST class-theta-1Glutathione transferase T1-1
- RS2266637 (GSTT1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
GSTT1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GSTT1
| Substances | Interaction | Organism | Category |
Substances That Decrease GSTT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.