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  3. GSTT1

GSTT1 (Glutathione S-transferase theta 1)

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Summary of GSTT1

GSTT1 is a theta class glutathione S-transferase . This enzyme has been claimed to have an important role in human carcinogenesis.

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The Function of GSTT1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Protein names

Recommended name:

Glutathione S-transferase theta-1

Alternative name(s):

GST class-theta-1
Glutathione transferase T1-1

GSTT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2266637 (GSTT1) ??

Top Gene-Substance Interactions

GSTT1 Interacts with These Diseases

Disease Score

Substances That Increase GSTT1

Substances Interaction Organism Category

Substances That Decrease GSTT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AhR
  • STAT3
  • STAT1
  • STAT1beta
  • STAT1alpha
  • AML1a
  • NF-1

Tissue specificity:

Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.

Gene Pathways:

  • Metabolism
  • Glutathione metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Drug metabolism - cytochrome P450

Molecular Function:

  • Glutathione Peroxidase Activity
  • Glutathione Transferase Activity

Biological Processes:

  • Glutathione Derivative Biosynthetic Process
  • Glutathione Metabolic Process

Drug Bank:

  • Carboplatin
  • Cisplatin
  • Etoposide
  • Oxaliplatin
  • Glutathione
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GST class-theta| AAEL009017-PA| AGAP000761-PA| BcDNA:RE63575| bmgstt| CG12930B| CG30000 gene product from transcript CG30000-RA| CG30000-PA| Dmel_CG30000| ENSANGG00000014930| glutathione S-transferase 1| Glutathione S-transferase 1 (theta)| glutathione S-transferase 5| glutathione S-transferase 8| glutathione S-transferase T1| Glutathione S transferase T1| glutathione S-transferase theta-1| glutathione S-transferase, theta 1| glutathione transferase T1-1| GST 5-5| GST8| GST-CL1| GST class-theta-1| Gstt1-1| GstT1-PA| GSTYRS| theta-class glutathione transferase| theta glutathione-S-transferase| gstt1

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