Summary of GSTP1
Glutathione S-transferase P1 (GSTP1) encodes glutathione S-transferases that play roles in detoxification (R).
GSTP1 is a phase II detoxification enzyme. It attaches glutathione to many types of toxins, reducing their activity and facilitating their elimination. Helps prevent neurodegeneration.
One polymorphism is associated with asthma (R). Loss of GSTP1 can increase the risk for cancer (R).
It's better to have this gene increased
most of the time.
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Protein names
Recommended name:
Glutathione S-transferase PShort name:
GSTP1-1Alternative name(s):
GST class-pi- RS1138272 (GSTP1) ??
- RS1695 (GSTP1) ??
- RS1871042 (GSTP1) ??
- RS6591256 (GSTP1) ??
- RS749174 (GSTP1) ??
- RS8191439 (GSTP1) ??
- RS947895 (GSTP1) ??
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Top Gene-Substance Interactions
GSTP1 Interacts with These Diseases
| Disease | Score |
Fixes
- Glutathione
- Lipoic Acid
- NAC
- DIM
- Sulforaphane
Substances That Increase GSTP1
| Substances | Interaction | Organism | Category |
Substances That Decrease GSTP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Dinitrosyl-Iron Complex Binding
- Drug Binding
- Glutathione Binding
- Glutathione Peroxidase Activity
- Glutathione Transferase Activity
- Jun Kinase Binding
- Kinase Regulator Activity
- Nitric Oxide Binding
- S-Nitrosoglutathione Binding
Biological Processes:
- Animal Organ Regeneration
- Cellular Response To Cell-Matrix Adhesion
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Response To Glucocorticoid Stimulus
- Cellular Response To Insulin Stimulus
- Cellular Response To Lipopolysaccharide
- Central Nervous System Development
- Common Myeloid Progenitor Cell Proliferation
- Glutathione Derivative Biosynthetic Process
- Glutathione Metabolic Process
- Linoleic Acid Metabolic Process
- Negative Regulation Of Acute Inflammatory Response
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Biosynthetic Process
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Interleukin-1 Beta Production
- Negative Regulation Of Jun Kinase Activity
- Negative Regulation Of Leukocyte Proliferation
- Negative Regulation Of Mapk Cascade
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Monocyte Chemotactic Protein-1 Production
- Negative Regulation Of Nitric-Oxide Synthase Biosynthetic Process
- Negative Regulation Of Protein Kinase Activity
- Negative Regulation Of Smooth Muscle Cell Chemotaxis
- Negative Regulation Of Stress-Activated Mapk Cascade
- Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
- Negative Regulation Of Tumor Necrosis Factor Production
- Negative Regulation Of Vascular Smooth Muscle Cell Proliferation
- Nitric Oxide Storage
- Oligodendrocyte Development
- Positive Regulation Of Superoxide Anion Generation
- Regulation Of Erk1 And Erk2 Cascade
- Regulation Of Stress-Activated Mapk Cascade
- Response To Amino Acid
- Response To Estradiol
- Response To Ethanol
- Response To L-Ascorbic Acid
- Response To Reactive Oxygen Species
- Xenobiotic Metabolic Process
- Response To Mercury Ion
Drug Bank:
- Carbocisteine
- Busulfan
- Carboplatin
- Chlorambucil
- Cisplatin
- Clomipramine
- Etoposide
- Glutathione
- Oxaliplatin
- Vitamin E