Summary of GSTP1
The GSTP1 gene codes for glutathione S-transferase pi 1 (GSTP1). GSTP1 is a phase II detoxification enzyme. It helps eliminate foreign chemicals (xenobiotics) such as drugs from our bodies [R, R].
GSTP1 also helps combat oxidative stress and inflammation [R, R, R].
GSTP1 variants are linked to [R, R, R, R]:
- Cancer
- Cancer treatment toxicity
- Diabetes
It's better to have this gene increased
most of the time.
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Protein names
Recommended name:
Glutathione S-transferase PShort name:
GSTP1-1Alternative name(s):
GST class-pi- RS1138272 (GSTP1) ??
- RS1695 (GSTP1) ??
- RS1871042 (GSTP1) ??
- RS614080 (GSTP1) ??
- RS6591256 (GSTP1) ??
- RS749174 (GSTP1) ??
- RS8191439 (GSTP1) ??
- RS947895 (GSTP1) ??
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Top Gene-Substance Interactions
GSTP1 Interacts with These Diseases
| Disease | Score |
Fixes
- Glutathione
- Lipoic Acid
- NAC
- DIM
- Sulforaphane
Substances That Increase GSTP1
| Substances | Interaction | Organism | Category |
Substances That Decrease GSTP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Glutathione Transferase Activity
- Glutathione Peroxidase Activity
- Drug Binding
- Jun Kinase Binding
- Kinase Regulator Activity
- S-Nitrosoglutathione Binding
- Dinitrosyl-Iron Complex Binding
- Glutathione Binding
- Nitric Oxide Binding
Biological Processes:
- Response To Reactive Oxygen Species
- Negative Regulation Of Acute Inflammatory Response
- Negative Regulation Of Protein Kinase Activity
- Glutathione Metabolic Process
- Xenobiotic Metabolic Process
- Central Nervous System Development
- Negative Regulation Of Biosynthetic Process
- Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
- Oligodendrocyte Development
- Animal Organ Regeneration
- Response To Estradiol
- Negative Regulation Of Interleukin-1 Beta Production
- Negative Regulation Of Tumor Necrosis Factor Production
- Cellular Response To Insulin Stimulus
- Regulation Of Stress-Activated Mapk Cascade
- Negative Regulation Of Stress-Activated Mapk Cascade
- Positive Regulation Of Superoxide Anion Generation
- Response To L-Ascorbic Acid
- Common Myeloid Progenitor Cell Proliferation
- Nitric Oxide Storage
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Response To Amino Acid
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Mapk Cascade
- Negative Regulation Of Jun Kinase Activity
- Linoleic Acid Metabolic Process
- Response To Ethanol
- Response To Mercury Ion
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of Nitric-Oxide Synthase Biosynthetic Process
- Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Leukocyte Proliferation
- Cellular Response To Lipopolysaccharide
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Response To Glucocorticoid Stimulus
- Cellular Response To Cell-Matrix Adhesion
- Negative Regulation Of Monocyte Chemotactic Protein-1 Production
- Negative Regulation Of Smooth Muscle Cell Chemotaxis
- Glutathione Derivative Biosynthetic Process
- Negative Regulation Of Vascular Smooth Muscle Cell Proliferation
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Drug Bank:
- Carbocisteine
- Busulfan
- Carboplatin
- Chlorambucil
- Cisplatin
- Clomipramine
- Etoposide
- Glutathione
- Oxaliplatin
- Vitamin E