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  3. GSTP1

GSTP1 (Glutathione S-transferase pi 1)

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Summary of GSTP1

Glutathione S-transferase P1 (GSTP1) encodes glutathione S-transferases that play roles in detoxification (R). 

GSTP1 is a phase II detoxification enzyme. It attaches glutathione to many types of toxins, reducing their activity and facilitating their elimination. Helps prevent neurodegeneration.

One polymorphism is associated with asthma (R). Loss of GSTP1 can increase the risk for cancer (R). 

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Protein names

Recommended name:

Glutathione S-transferase P

Short name:

GSTP1-1

Alternative name(s):

GST class-pi

GSTP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1138272 (GSTP1) ??
  2. RS1695 (GSTP1) ??
  3. RS1871042 (GSTP1) ??
  4. RS614080 (GSTP1) ??
  5. RS6591256 (GSTP1) ??
  6. RS749174 (GSTP1) ??
  7. RS8191439 (GSTP1) ??
  8. RS947895 (GSTP1) ??

Top Gene-Substance Interactions

GSTP1 Interacts with These Diseases

Disease Score

Fixes

  • Glutathione
  • Lipoic Acid
  • NAC
  • DIM
  • Sulforaphane

Substances That Increase GSTP1

Substances Interaction Organism Category

Substances That Decrease GSTP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • GR-alpha
  • GR-beta
  • p53
  • AhR
  • Nkx3-1 v1
  • Nkx3-1

Gene Pathways:

  • Pathways in cancer
  • Metabolism of xenobiotics by cytochrome P450
  • Drug metabolism - cytochrome P450
  • Glutathione metabolism
  • Cellular responses to stress
  • Prostate cancer
  • Metabolism

Molecular Function:

  • Dinitrosyl-Iron Complex Binding
  • Drug Binding
  • Glutathione Binding
  • Glutathione Peroxidase Activity
  • Glutathione Transferase Activity
  • Jun Kinase Binding
  • Kinase Regulator Activity
  • Nitric Oxide Binding
  • S-Nitrosoglutathione Binding

Biological Processes:

  • Animal Organ Regeneration
  • Cellular Response To Cell-Matrix Adhesion
  • Cellular Response To Epidermal Growth Factor Stimulus
  • Cellular Response To Glucocorticoid Stimulus
  • Cellular Response To Insulin Stimulus
  • Cellular Response To Lipopolysaccharide
  • Central Nervous System Development
  • Common Myeloid Progenitor Cell Proliferation
  • Glutathione Derivative Biosynthetic Process
  • Glutathione Metabolic Process
  • Linoleic Acid Metabolic Process
  • Negative Regulation Of Acute Inflammatory Response
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Biosynthetic Process
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Fibroblast Proliferation
  • Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Negative Regulation Of Interleukin-1 Beta Production
  • Negative Regulation Of Jun Kinase Activity
  • Negative Regulation Of Leukocyte Proliferation
  • Negative Regulation Of Mapk Cascade
  • Negative Regulation Of Map Kinase Activity
  • Negative Regulation Of Monocyte Chemotactic Protein-1 Production
  • Negative Regulation Of Nitric-Oxide Synthase Biosynthetic Process
  • Negative Regulation Of Protein Kinase Activity
  • Negative Regulation Of Smooth Muscle Cell Chemotaxis
  • Negative Regulation Of Stress-Activated Mapk Cascade
  • Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
  • Negative Regulation Of Tumor Necrosis Factor Production
  • Negative Regulation Of Vascular Smooth Muscle Cell Proliferation
  • Nitric Oxide Storage
  • Oligodendrocyte Development
  • Positive Regulation Of Superoxide Anion Generation
  • Regulation Of Erk1 And Erk2 Cascade
  • Regulation Of Stress-Activated Mapk Cascade
  • Response To Amino Acid
  • Response To Estradiol
  • Response To Ethanol
  • Response To L-Ascorbic Acid
  • Response To Reactive Oxygen Species
  • Xenobiotic Metabolic Process
  • Response To Mercury Ion

Drug Bank:

  • Carbocisteine
  • Busulfan
  • Carboplatin
  • Chlorambucil
  • Cisplatin
  • Clomipramine
  • Etoposide
  • Glutathione
  • Oxaliplatin
  • Vitamin E
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_000242012| chain 7| deafness, X-linked 7| DFN7| epididymis secretory protein Li 22| fa02f07| FAEES3| fatty acid ethyl ester synthase III| glutathione S-transferase P| glutathione S-transferase P1| glutathione S-transferase P 1| glutathione S-transferase P1-1 class| glutathione S-transferase pi| glutathione S-transferase, pi 1| glutathione S-transferase, pi 2| Glutathione-S-transferase, placental enzyme pi type| glutathione S-transferase P-like protein| Gst3| GST 7-7| GST class-pi| GSTP| GST-P| gst P1| Gst p-1| GSTP1-1| Gstp2| gst-pi| GstpiB| GST-piB| GST pi enzyme| GST-pi enzyme| GST YF-YF| HEL-S-22| I79_018157| MDA_GLEAN10017817| PI| preadipocyte growth factor| Y1Q_002147| gstp1

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