Summary of GSTP1
Glutathione S-transferase P1 (GSTP1) encodes glutathione S-transferases that play roles in detoxification (R).
GSTP1 is a phase II detoxification enzyme. It attaches glutathione to many types of toxins, reducing their activity and facilitating their elimination. Helps prevent neurodegeneration.
One polymorphism is associated with asthma (R). Loss of GSTP1 can increase the risk for cancer (R).
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Protein names
Recommended name:
Glutathione S-transferase PShort name:
GSTP1-1Alternative name(s):
GST class-pi- RS1138272 (GSTP1) ??
- RS1695 (GSTP1) ??
- RS1871042 (GSTP1) ??
- RS6591256 (GSTP1) ??
- RS749174 (GSTP1) ??
- RS8191439 (GSTP1) ??
- RS947895 (GSTP1) ??
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Top Gene-Substance Interactions
GSTP1 Interacts with These Diseases
| Disease | Score |
Fixes
- Glutathione
- Lipoic Acid
- NAC
- DIM
- Sulforaphane
Substances That Increase GSTP1
| Substances | Interaction | Organism | Category |
Substances That Decrease GSTP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Glutathione Transferase Activity
- Glutathione Peroxidase Activity
- Drug Binding
- Jun Kinase Binding
- Kinase Regulator Activity
- S-Nitrosoglutathione Binding
- Dinitrosyl-Iron Complex Binding
- Glutathione Binding
- Nitric Oxide Binding
Biological Processes:
- Response To Reactive Oxygen Species
- Negative Regulation Of Acute Inflammatory Response
- Negative Regulation Of Protein Kinase Activity
- Glutathione Metabolic Process
- Xenobiotic Metabolic Process
- Central Nervous System Development
- Negative Regulation Of Biosynthetic Process
- Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
- Oligodendrocyte Development
- Animal Organ Regeneration
- Response To Estradiol
- Negative Regulation Of Interleukin-1 Beta Production
- Negative Regulation Of Tumor Necrosis Factor Production
- Cellular Response To Insulin Stimulus
- Regulation Of Stress-Activated Mapk Cascade
- Negative Regulation Of Stress-Activated Mapk Cascade
- Positive Regulation Of Superoxide Anion Generation
- Response To L-Ascorbic Acid
- Common Myeloid Progenitor Cell Proliferation
- Nitric Oxide Storage
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Response To Amino Acid
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Mapk Cascade
- Negative Regulation Of Jun Kinase Activity
- Linoleic Acid Metabolic Process
- Response To Ethanol
- Response To Mercury Ion
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of Nitric-Oxide Synthase Biosynthetic Process
- Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Leukocyte Proliferation
- Cellular Response To Lipopolysaccharide
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Response To Glucocorticoid Stimulus
- Cellular Response To Cell-Matrix Adhesion
- Negative Regulation Of Monocyte Chemotactic Protein-1 Production
- Negative Regulation Of Smooth Muscle Cell Chemotaxis
- Glutathione Derivative Biosynthetic Process
- Negative Regulation Of Vascular Smooth Muscle Cell Proliferation
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Drug Bank:
- Carbocisteine
- Busulfan
- Carboplatin
- Chlorambucil
- Cisplatin
- Clomipramine
- Etoposide
- Glutathione
- Oxaliplatin
- Vitamin E