• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. GSTO1

GSTO1 (Glutathione S-transferase omega 1)

Loading...

Summary of GSTO1

This gene encodes a protein that is involved in the metabolism of xenobiotics and carcinogens (R).

0 users want this gene increased, 0 users want it decreased

The Function of GSTO1

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Protein names

Recommended name:

Glutathione S-transferase omega-1

Short name:

MMA(V

Alternative name(s):

GSTO-1
Glutathione S-transferase omega 1-1
GSTO 1-1
Glutathione-dependent dehydroascorbate reductase
Monomethylarsonic acid reductase
S-(Phenacyl
SPG-R

GSTO1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4925 (GSTO1) ??

Top Gene-Substance Interactions

GSTO1 Interacts with These Diseases

Disease Score

Substances That Increase GSTO1

Substances Interaction Organism Category

Substances That Decrease GSTO1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.

Gene Pathways:

  • Metabolism
  • Disease
  • Glutathione metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Drug metabolism - cytochrome P450

Enzyme Regulation:

Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.

Molecular Function:

  • Glutathione Dehydrogenase (Ascorbate) Activity
  • Glutathione Transferase Activity
  • Methylarsonate Reductase Activity
  • Oxidoreductase Activity

Biological Processes:

  • Cellular Response To Arsenic-Containing Substance
  • Glutathione Derivative Biosynthetic Process
  • Glutathione Metabolic Process
  • L-Ascorbic Acid Metabolic Process
  • Methylation
  • Negative Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
  • Positive Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
  • Positive Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion
  • Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
  • Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
  • Xenobiotic Catabolic Process
  • L-Ascorbic Acid Biosynthetic Process

Drug Bank:

  • Vitamin E
  • Glutathione
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| P28| AAEL017085-PA| AGAP005749-PA| AS28_07799| CG6662 gene product from transcript CG6662-RA| CG6662-PA| Dmel_CG6662| ENSANGG00000016246| epididymis secretory protein Li 21| fd58h04| glutathione-dependent dehydroascorbate reductase| glutathione-S-transferase like| glutathione S-transferase O1| Glutathione S transferase O1| glutathione-S-transferase omega 1| Glutathione S-transferase omega-1| glutathione S-transferase omega 1-1| glutathione S-transferase omega 2| Glutathione transferase omega-1| Glutathione transferase omega 1 (GSTO 1-1) (p28)| GSTO-1| GSTO 1-1| GstO1-PA| gsto2| GSTTLp28| Gstx| GW7_16586| H920_06294| HEL-S-21| I79_024438| MDA_GLEAN10023325| MMA(V) reductase| monomethylarsonic acid reductase| N300_12454| N302_13627| N303_01685| N309_06840| N310_00769| N311_12538| N312_09346| N321_06727| N322_11195| N324_01487| N326_11229| N327_03683| N328_05694| N329_12427| N331_00361| N334_04728| N336_07671| N341_10079| omega class glutathione-S-transferase| PAL_GLEAN10014216| PANDA_001808| pyrimidodiazepine synthase| Spg-r| S-(Phenacyl)glutathione reductase| TREES_T100016520| UY3_05199| Y1Q_001851| gsto1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved