Summary of GSTO1
This gene encodes a protein that is involved in the metabolism of xenobiotics and carcinogens (R).
The Function of GSTO1
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Protein names
Recommended name:
Glutathione S-transferase omega-1Short name:
MMA(VAlternative name(s):
GSTO-1Glutathione S-transferase omega 1-1
GSTO 1-1
Glutathione-dependent dehydroascorbate reductase
Monomethylarsonic acid reductase
S-(Phenacyl
SPG-R
- RS4925 (GSTO1) ??
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Top Gene-Substance Interactions
GSTO1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GSTO1
| Substances | Interaction | Organism | Category |
Substances That Decrease GSTO1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
Gene Pathways:
Enzyme Regulation:
Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
Molecular Function:
- Glutathione Dehydrogenase (Ascorbate) Activity
- Glutathione Transferase Activity
- Methylarsonate Reductase Activity
- Oxidoreductase Activity
Biological Processes:
- Cellular Response To Arsenic-Containing Substance
- Glutathione Derivative Biosynthetic Process
- Glutathione Metabolic Process
- L-Ascorbic Acid Metabolic Process
- Methylation
- Negative Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Positive Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Positive Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion
- Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
- Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
- Xenobiotic Catabolic Process
- L-Ascorbic Acid Biosynthetic Process