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  3. GSTA2

GSTA2 (Glutathione S-transferase alpha 2)

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Summary of GSTA2

The gene codes for a protein, glutathione S-transferase alpha 2. Variations can affect the toxicity and effectiveness of some drugs [R].

0 users want this gene increased, 0 users want it decreased

The Function of GSTA2

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Protein names

Recommended name:

Glutathione S-transferase A2

Short name:

GTH2

Alternative name(s):

GST HA subunit 2
GST class-alpha member 2
GST-gamma
GSTA2-2

GSTA2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2180314 (GSTA2) ??
  2. RS2234951 (GSTA2) ??

Top Gene-Substance Interactions

GSTA2 Interacts with These Diseases

Disease Score

Substances That Increase GSTA2

Substances Interaction Organism Category

Substances That Decrease GSTA2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • HNF-1A
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • PPAR-alpha
  • HNF-1
  • C/EBPbeta
  • C/EBPalpha

Tissue specificity:

Liver.

Gene Pathways:

  • Metabolism
  • Glutathione metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Drug metabolism - cytochrome P450

Molecular Function:

  • Glutathione Transferase Activity

Biological Processes:

  • Epithelial Cell Differentiation
  • Glutathione Derivative Biosynthetic Process
  • Glutathione Metabolic Process

Drug Bank:

  • Busulfan
  • Chloroquine
  • Clofibrate
  • Ethacrynic Acid
  • Glutathione
  • Vitamin E
  • Azathioprine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

glutathione S-transferase A1| GST class-alpha member 1| glutathione S-alkyltransferase A2| glutathione S-aralkyltransferase A2| glutathione S-aryltransferase A2| glutathione S-transferase| glutathione S-transferase A2| glutathione S-transferase alpha-1| glutathione S-transferase, alpha 2 (Yc2)| glutathione S-transferase alpha class A2| glutathione-S-transferase, alpha type2| Glutathione-S-transferase alpha type (Yc?)| glutathione S-transferase GT41A| glutathione S-transferase Ya-1| glutathione S-transferase Ya subunit| GST 1-1| GST 1a-1a| GST2| Gst2-2| Gsta1| GST A1-1| GST A2-2| GSTA2-2| GST Alpha 2-2| GST B| Gstc2| Gstc-2| GST class-alpha member 2| GST-gamma| GST HA subunit 2| GST Ya1| GTA2| GTH2| ligandin| liver GST2| S-(hydroxyalkyl)glutathione lyase A2| testis tissue sperm-binding protein Li 59n| gsta2

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