Summary of GRM3
This gene encodes a glutamate metabotropic receptor, which is needed for normal brain function (R).
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The Function of GRM3
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Protein names
Recommended name:
Metabotropic glutamate receptor 3Alternative name(s):
mGluR3- RS12704290 (GRM3) ??
- RS1468412 (GRM3) ??
- RS2189812 (GRM3) ??
- RS6465084 (GRM3) ??
- RS724226 (GRM3) ??
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Top Gene-Substance Interactions
GRM3 Interacts with These Diseases
| Disease | Score |
Substances That Increase GRM3
| Substances | Interaction | Organism | Category |
Substances That Decrease GRM3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
Molecular Function:
- Calcium Channel Regulator Activity
- Glutamate Receptor Activity
- G-Protein Coupled Receptor Activity
- Group Ii Metabotropic Glutamate Receptor Activity
Biological Processes:
- Adenylate Cyclase-Inhibiting G-Protein Coupled Glutamate Receptor Signaling Pathway
- Chemical Synaptic Transmission
- Negative Regulation Of Adenylate Cyclase Activity
- Regulation Of Synaptic Transmission, Glutamatergic