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  3. GRM3

GRM3 (Glutamate metabotropic receptor 3)

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Summary of GRM3

This gene encodes a glutamate metabotropic receptor, which is needed for normal brain function (R).

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The Function of GRM3

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Protein names

Recommended name:

Metabotropic glutamate receptor 3

Alternative name(s):

mGluR3

GRM3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12704290 (GRM3) ??
  2. RS1468412 (GRM3) ??
  3. RS2189812 (GRM3) ??
  4. RS6465084 (GRM3) ??
  5. RS724226 (GRM3) ??

Top Gene-Substance Interactions

GRM3 Interacts with These Diseases

Disease Score

Substances That Increase GRM3

Substances Interaction Organism Category

Substances That Decrease GRM3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB

Tissue specificity:

Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Glutamatergic synapse

Molecular Function:

  • Calcium Channel Regulator Activity
  • Glutamate Receptor Activity
  • G-Protein Coupled Receptor Activity
  • Group Ii Metabotropic Glutamate Receptor Activity

Biological Processes:

  • Adenylate Cyclase-Inhibiting G-Protein Coupled Glutamate Receptor Signaling Pathway
  • Chemical Synaptic Transmission
  • Negative Regulation Of Adenylate Cyclase Activity
  • Regulation Of Synaptic Transmission, Glutamatergic
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_14142| AS27_15259| AS28_04740| CB1_001687006| D623_10005191| EGK_13973| GLUR3| glutamate receptor, metabotropic 3| Gprc1c| G protein-coupled receptor, family C, group 1, member C| GW7_15125| I79_018744| M959_12609| metabotropic glutamate receptor 3| metabotropic type gluatamate receptor 3| mGlu3| MGLUR3| N300_00475| N301_07909| N302_08383| N303_08214| N305_10406| N306_11519| N308_07087| N309_03582| N320_12059| N322_00719| N326_11022| N329_02458| N332_11942| N333_01387| N335_13427| N336_01891| N339_08150| N340_13811| N341_00394| PAL_GLEAN10013646| PANDA_001844| TREES_T100015161| UY3_08130| Y1Q_029048| Y956_03930| Z169_02271| grm3

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