The Function of GRK6
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
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Protein names
Recommended name:
G protein-coupled receptor kinase 6Alternative name(s):
G protein-coupled receptor kinase GRK6Top Gene-Substance Interactions
GRK6 Interacts with These Diseases
| Disease | Score |
Substances That Increase GRK6
| Substances | Interaction | Organism | Category |
Substances That Decrease GRK6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed.
Gene Pathways:
Molecular Function:
Biological Processes:
- Desensitization Of G-Protein Coupled Receptor Protein Signaling Pathway
- Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
- Negative Regulation Of Anion Channel Activity
- Wnt Signaling Pathway