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  3. GRK6

GRK6 (G protein-coupled receptor kinase 6)

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The Function of GRK6

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

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Protein names

Recommended name:

G protein-coupled receptor kinase 6

Alternative name(s):

G protein-coupled receptor kinase GRK6

Top Gene-Substance Interactions

GRK6 Interacts with These Diseases

Disease Score

Substances That Increase GRK6

Substances Interaction Organism Category

Substances That Decrease GRK6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta

Tissue specificity:

Widely expressed.

Gene Pathways:

  • Chemokine signaling pathway

Molecular Function:

  • Atp Binding
  • Beta-Adrenergic Receptor Kinase Activity
  • G-Protein Coupled Receptor Kinase Activity

Biological Processes:

  • Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
  • Wnt Signaling Pathway
  • Desensitization Of G-Protein Coupled Receptor Protein Signaling Pathway
  • Negative Regulation Of Anion Channel Activity
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14448| AS27_11922| AS28_10239| CB1_000228048| D623_10032499| GPRK6| g protein-coupled receptor kinase GRK6| M91_05842| M959_08343| MDA_GLEAN10021206| N300_13019| N301_00641| N302_05336| N303_03079| N305_05772| N306_11199| N307_13773| N308_15029| N309_00427| N310_07186| N311_08019| N312_05279| N320_02434| N321_07941| N322_08758| N324_01821| N325_10632| N326_02659| N327_03017| N328_04203| N329_05273| N330_09104| N331_08895| N332_10241| N333_09676| N334_09197| N335_09808| N336_04780| N339_07952| N341_06207| PAL_GLEAN10016950| PANDA_018098| TREES_T100010123| UY3_11924| Y956_04303| Z169_09329| grk6

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