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  3. GRIN2B

GRIN2B (Glutamate ionotropic receptor NMDA type subunit 2B)

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Summary of GRIN2B

This gene encodes for ionotropic glutamate receptors. It is involved with memory and learning (R). 

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The Function of GRIN2B

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Protein names

Recommended name:

Glutamate receptor ionotropic, NMDA 2B

Short name:

NR3

Alternative name(s):

GluN2B
Glutamate [NMDA] receptor subunit epsilon-2
N-methyl D-aspartate receptor subtype 2B
NMDAR2B
NR2B
N-methyl-D-aspartate receptor subunit 3
hNR3

GRIN2B SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1019385 (GRIN2B) ??
  2. RS10845840 (GRIN2B) ??
  3. RS11055612 (GRIN2B) ??
  4. RS117578877 (GRIN2B) ??
  5. RS12422552 (GRIN2B) ??
  6. RS1457614 (GRIN2B) ??
  7. RS1531228 (GRIN2B) ??
  8. RS17221259 (GRIN2B) ??
  9. RS1805476 (GRIN2B) ??
  10. RS1805502 (GRIN2B) ??
  11. RS1806201 (GRIN2B) ??
  12. RS2160519 (GRIN2B) ??
  13. RS2268118 (GRIN2B) ??
  14. RS4764039 (GRIN2B) ??
  15. RS4764043 (GRIN2B) ??
  16. RS6488619 (GRIN2B) ??
  17. RS7301328 (GRIN2B) ??
  18. RS7313149 (GRIN2B) ??
  19. RS78791096 (GRIN2B) ??
  20. RS890 (GRIN2B) ??

Top Gene-Substance Interactions

GRIN2B Interacts with These Diseases

Disease Score

Substances That Increase GRIN2B

Substances Interaction Organism Category

Substances That Decrease GRIN2B

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Epileptic encephalopathy, early infantile, 27Mental retardation, autosomal dominant 6From UniProt: Mental retardation, autosomal dominant 6 (MRD6): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. [MIM:613970] A chromosomal aberrations involving GRIN2B has been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1. Epileptic encephalopathy, early infantile, 27 (EIEE27): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. [MIM:616139]

     From NCBI Gene: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate . This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008] From UniProt: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • Sp1

Tissue specificity:

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Amyotrophic lateral sclerosis (ALS)
  • Alzheimer's disease
  • Glutamatergic synapse
  • Neuronal System
  • Systemic lupus erythematosus
  • Huntington's disease
  • Long-term potentiation

Molecular Function:

  • Extracellular-Glutamate-Gated Ion Channel Activity
  • Glycine Binding
  • Nmda Glutamate Receptor Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity
  • Zinc Ion Binding

Biological Processes:

  • Chemical Synaptic Transmission
  • Ephrin Receptor Signaling Pathway
  • Glutamate Receptor Signaling Pathway
  • Learning Or Memory
  • Mapk Cascade
  • Response To Ethanol
  • Transport

Drug Bank:

  • Atomoxetine
  • Pethidine
  • Acetylcysteine
  • Felbamate
  • Gabapentin
  • Haloperidol
  • Ketobemidone
  • Memantine
  • Milnacipran
  • Pentobarbital
  • Phenobarbital
  • Secobarbital
  • Acamprosate
  • Ifenprodil
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| glutamate-like protein| Anapl_01052| AS27_07948| AS28_12551| CB1_001683033| D623_10031463| EGK_03413| EIEE27| GluN2B| GluRepsilon2| glutamate [NMDA] receptor subunit epsilon 2| Glutamate [NMDA] receptor subunit epsilon-2| Glutamate NMDA receptor subunit epsilon-2| glutamate receptor, ionotropic, NMDA2B| Glutamate receptor ionotropic, NMDA 2B| glutamate receptor, ionotropic, NMDA2B (epsilon 2)| glutamate receptor, ionotropic, N-methyl D-aspartate 2B| glutamate receptor subunit epsilon-2| GW7_02411| H920_11379| hNR3| I79_011493| M959_06730| MRD6| N300_13145| N301_05888| N302_12789| N303_02797| N305_13947| N306_07415| N307_05036| N308_03353| N309_00458| N310_12061| N320_13210| N321_03613| N324_00855| N325_07953| N326_00706| N328_08276| N330_00914| N332_14945| N333_05470| N335_09168| N339_03330| N340_05671| Nmdar2b| NMDA type glutamate receptor| N-methyl D-aspartate receptor 2B| N-methyl D-aspartate receptor subtype 2B| N-methyl-D-aspartate receptor subunit 2B| N-methyl-D-aspartate receptor subunit 3| NR2B| NR3| PAL_GLEAN10015632| PANDA_006399| TREES_T100017348| UY3_11050| Y1Q_006641| Y956_01288| Z169_12116| grin2b

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