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  3. GRIN1

GRIN1 (Glutamate ionotropic receptor NMDA type subunit 1)

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Summary of GRIN1

The gene codes for a protein, glutamate ionotropic receptor NMDA type subunit 1. It plays a role in the plasticity of synapses [R].

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The Function of GRIN1

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Protein names

Recommended name:

Glutamate receptor ionotropic, NMDA 1

Alternative name(s):

GluN1
Glutamate [NMDA] receptor subunit zeta-1
N-methyl-D-aspartate receptor subunit NR1
NMD-R1

GRIN1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11146020 (GRIN1) ??

Top Gene-Substance Interactions

GRIN1 Interacts with These Diseases

Disease Score

Substances That Increase GRIN1

Substances Interaction Organism Category

Substances That Decrease GRIN1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Mental retardation, autosomal dominant 8From UniProt: Mental retardation, autosomal dominant 8 (MRD8): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. [MIM:614254]

     From NCBI Gene: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] From UniProt: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • c-Fos

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Amyotrophic lateral sclerosis (ALS)
  • Alzheimer's disease
  • Glutamatergic synapse
  • Neuronal System
  • Huntington's disease
  • Long-term potentiation

Molecular Function:

  • Calcium Channel Activity
  • Calcium Ion Binding
  • Calmodulin Binding
  • Extracellular-Glutamate-Gated Ion Channel Activity
  • Glutamate Binding
  • Glycine Binding
  • Neurotransmitter Binding
  • Nmda Glutamate Receptor Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity
  • Voltage-Gated Cation Channel Activity

Biological Processes:

  • Adult Locomotory Behavior
  • Calcium Ion Homeostasis
  • Cation Transport
  • Cellular Calcium Ion Homeostasis
  • Cerebral Cortex Development
  • Chemical Synaptic Transmission
  • Conditioned Taste Aversion
  • Ephrin Receptor Signaling Pathway
  • Excitatory Postsynaptic Potential
  • Ionotropic Glutamate Receptor Signaling Pathway
  • Long-Term Memory
  • Male Mating Behavior
  • Mapk Cascade
  • Negative Regulation Of Neuron Apoptotic Process
  • Olfactory Learning
  • Pons Maturation
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Excitatory Postsynaptic Potential
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Prepulse Inhibition
  • Propylene Metabolic Process
  • Regulation Of Axonogenesis
  • Regulation Of Dendrite Morphogenesis
  • Regulation Of Long-Term Neuronal Synaptic Plasticity
  • Regulation Of Membrane Potential
  • Regulation Of Respiratory Gaseous Exchange
  • Regulation Of Synapse Assembly
  • Respiratory Gaseous Exchange
  • Response To Amphetamine
  • Response To Ethanol
  • Response To Morphine
  • Sensory Perception Of Pain
  • Social Behavior
  • Suckling Behavior
  • Synaptic Transmission, Glutamatergic
  • Visual Learning
  • Cellular Response To Manganese Ion
  • Protein Tetramerization
  • Response To Calcium Ion
  • Response To Fungicide
  • Rhythmic Process

Drug Bank:

  • Atomoxetine
  • Pethidine
  • Acetylcysteine
  • Gabapentin
  • Ifenprodil
  • Ketobemidone
  • Memantine
  • Orphenadrine
  • Pentobarbital
  • Phenobarbital
  • Secobarbital
  • Acamprosate
  • Milnacipran
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GluRdelta1| A306_11534| AS27_11792| AS28_10700| CB1_000180005| D623_10013879| GluN1| GluRzeta1| glutamate (NMDA) receptor subunit zeta-1| glutamate [NMDA] receptor subunit zeta-1| glutamate [NMDA] receptor subunit zeta-1 isoform NR1-1| glutamate [NMDA] receptor subunit zeta-1 isoform NR1-2| glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3| glutamate [NMDA] receptor subunit zeta-1 isoform NR1-4| glutamate receptor ionotropic, NMDA 1| glutamate receptor, ionotropic, NMDA1 (zeta 1)| glutamate receptor, ionotropic, N-methyl D-aspartate 1| glutamate receptor NMDA 1| glutamate receptor subunit NR1| glutamate receptor subunit zeta 1| H920_17103| I79_022712| M100174| M91_20555| M959_02248| MRD8| N300_08013| N301_09837| N303_11270| N305_07734| N307_07533| N308_04815| N309_12492| N310_05106| N311_07061| N312_07834| N320_03611| N321_08153| N324_10560| N325_11884| N326_02896| N327_04386| N328_05636| N330_04504| N332_02015| N333_04791| N335_11311| N340_05054| N341_04768| neurotransmitter receptor| NMDA1| Nmdar| nmdar1| NMDAR1 glutamate receptor subunit| NMDA R1 receptor C1 cassette| NMD-R1| N-methyl D-aspartate 1 glutamate receptor| N-methyl-D-aspartate glutamate receptor| N-methyl-D-aspartate receptor| N-methyl-D-aspartate receptor 1| N-methyl-D-aspartate receptor channel, subunit zeta-1| N-methyl-D-aspartate receptor subunit NR1| N-methyl-D-aspartate receptor type 1| NR1| PAL_GLEAN10012725| PANDA_015809| Rgsc174| TREES_T100011180| Y1Q_017255| Y956_15903| Z169_02105| grin1

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