Summary of GRIN1
The gene codes for a protein, glutamate ionotropic receptor NMDA type subunit 1. It plays a role in the plasticity of synapses [R].
The Function of GRIN1
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Protein names
Recommended name:
Glutamate receptor ionotropic, NMDA 1Alternative name(s):
GluN1Glutamate [NMDA] receptor subunit zeta-1
N-methyl-D-aspartate receptor subunit NR1
NMD-R1
- RS11146020 (GRIN1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
GRIN1 Interacts with These Diseases
Disease | Score |
Substances That Increase GRIN1
Substances | Interaction | Organism | Category |
Substances That Decrease GRIN1
Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Mental retardation, autosomal dominant 8From UniProt: Mental retardation, autosomal dominant 8 (MRD8): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. [MIM:614254]
From NCBI Gene: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] From UniProt: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Calcium Channel Activity
- Calcium Ion Binding
- Calmodulin Binding
- Extracellular-Glutamate-Gated Ion Channel Activity
- Glutamate Binding
- Glycine Binding
- Neurotransmitter Binding
- Nmda Glutamate Receptor Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Voltage-Gated Cation Channel Activity
Biological Processes:
- Adult Locomotory Behavior
- Calcium Ion Homeostasis
- Cation Transport
- Cellular Calcium Ion Homeostasis
- Cerebral Cortex Development
- Chemical Synaptic Transmission
- Conditioned Taste Aversion
- Ephrin Receptor Signaling Pathway
- Excitatory Postsynaptic Potential
- Ionotropic Glutamate Receptor Signaling Pathway
- Long-Term Memory
- Male Mating Behavior
- Mapk Cascade
- Negative Regulation Of Neuron Apoptotic Process
- Olfactory Learning
- Pons Maturation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Excitatory Postsynaptic Potential
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Prepulse Inhibition
- Propylene Metabolic Process
- Regulation Of Axonogenesis
- Regulation Of Dendrite Morphogenesis
- Regulation Of Long-Term Neuronal Synaptic Plasticity
- Regulation Of Membrane Potential
- Regulation Of Respiratory Gaseous Exchange
- Regulation Of Synapse Assembly
- Respiratory Gaseous Exchange
- Response To Amphetamine
- Response To Ethanol
- Response To Morphine
- Sensory Perception Of Pain
- Social Behavior
- Suckling Behavior
- Synaptic Transmission, Glutamatergic
- Visual Learning
- Cellular Response To Manganese Ion
- Protein Tetramerization
- Response To Calcium Ion
- Response To Fungicide
- Rhythmic Process
Drug Bank:
- Atomoxetine
- Pethidine
- Acetylcysteine
- Gabapentin
- Ifenprodil
- Ketobemidone
- Memantine
- Orphenadrine
- Pentobarbital
- Phenobarbital
- Secobarbital
- Acamprosate
- Milnacipran