From NCBI Gene: Mental retardation, autosomal dominant 8From UniProt: Mental retardation, autosomal dominant 8 (MRD8): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. [MIM:614254]

     From NCBI Gene: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] From UniProt: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

The following transcription factors affect gene expression:

• Egr-1
• c-Fos

Molecular Function:

• Nmda Glutamate Receptor Activity
• Ras Guanyl-Nucleotide Exchange Factor Activity
• Extracellular-Glutamate-Gated Ion Channel Activity
• Calcium Channel Activity
• Calcium Ion Binding
• Calmodulin Binding
• Glycine Binding
• Glutamate Binding
• Voltage-Gated Cation Channel Activity
• Neurotransmitter Binding

Biological Processes:

• Mapk Cascade
• Conditioned Taste Aversion
• Suckling Behavior
• Response To Amphetamine
• Cation Transport
• Cellular Calcium Ion Homeostasis
• Chemical Synaptic Transmission
• Respiratory Gaseous Exchange
• Long-Term Memory
• Adult Locomotory Behavior
• Olfactory Learning
• Visual Learning
• Propylene Metabolic Process
• Sensory Perception Of Pain
• Pons Maturation
• Cerebral Cortex Development
• Social Behavior
• Ionotropic Glutamate Receptor Signaling Pathway
• Synaptic Transmission, Glutamatergic
• Regulation Of Membrane Potential
• Positive Regulation Of Apoptotic Process
• Response To Morphine
• Negative Regulation Of Neuron Apoptotic Process
• Regulation Of Respiratory Gaseous Exchange
• Response To Ethanol
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
• Ephrin Receptor Signaling Pathway
• Regulation Of Long-Term Neuronal Synaptic Plasticity
• Rhythmic Process
• Regulation Of Dendrite Morphogenesis
• Regulation Of Axonogenesis
• Protein Tetramerization
• Response To Calcium Ion
• Regulation Of Synapse Assembly
• Calcium Ion Homeostasis
• Excitatory Postsynaptic Potential
• Prepulse Inhibition
• Male Mating Behavior
• Response To Fungicide
• Cellular Response To Manganese Ion
• Positive Regulation Of Excitatory Postsynaptic Potential

Drug Bank:

• Atomoxetine
• Pethidine
• Acetylcysteine
• Gabapentin
• Ifenprodil
• Ketobemidone
• Memantine
• Orphenadrine
• Pentobarbital
• Phenobarbital
• Secobarbital
• Acamprosate
• Milnacipran