The Function of GRHL3
Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).
Protein names
Recommended name:
Grainyhead-like protein 3 homologAlternative name(s):
Sister of mammalian grainyheadTranscription factor CP2-like 4
- RS6691722 (GRHL3) ??
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Top Gene-Substance Interactions
GRHL3 Interacts with These Diseases
| Disease | Score |
Substances That Increase GRHL3
| Substances | Interaction | Organism | Category |
Substances That Decrease GRHL3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific.
Molecular Function:
- Chromatin Dna Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
Biological Processes:
- Central Nervous System Development
- Cochlea Morphogenesis
- Ectoderm Development
- Epidermis Development
- Establishment Of Planar Polarity
- Establishment Of Skin Barrier
- Eyelid Development In Camera-Type Eye
- Neural Tube Closure
- Pattern Specification Process
- Planar Cell Polarity Pathway Involved In Neural Tube Closure
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Actin Cytoskeleton Organization
- Wound Healing