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  3. GRB7

GRB7 (Growth factor receptor bound protein 7)

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The Function of GRB7

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.

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Protein names

Recommended name:

Growth factor receptor-bound protein 7

Short name:

B47

Alternative name(s):

Epidermal growth factor receptor GRB-7
GRB7 adapter protein

GRB7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12946510 (GRB7) ??

Top Gene-Substance Interactions

GRB7 Interacts with These Diseases

Disease Score

Substances That Increase GRB7

Substances Interaction Organism Category

Substances That Decrease GRB7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Gene Pathways:

  • Signal Transduction
  • Hemostasis

Molecular Function:

  • Phosphatidylinositol Binding
  • Protein Kinase Binding
  • Rna Binding
  • Sh3/Sh2 Adaptor Activity
  • Identical Protein Binding

Biological Processes:

  • Epidermal Growth Factor Receptor Signaling Pathway
  • Erbb2 Signaling Pathway
  • Leukocyte Migration
  • Negative Regulation Of Translation
  • Positive Regulation Of Cell Migration
  • Stress Granule Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_15439| B47| CB1_000261011| EGK_08638| epidermal growth factor receptor GRB-7| GRB7 adapter protein| growth factor receptor binding protein GRB7| growth factor receptor-bound protein 7| Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7)| growth factor receptor-bound protein 7-like protein| H920_03591| I79_005728| M959_01473| N300_06113| N302_08148| N307_06911| PAL_GLEAN10019613| Retinol dehydrogenase 8| TREES_T100004475| UY3_09126| Y1Q_002635| grb7

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