The Function of GRB7
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.
Protein names
Recommended name:
Growth factor receptor-bound protein 7Short name:
B47Alternative name(s):
Epidermal growth factor receptor GRB-7GRB7 adapter protein
- RS12946510 (GRB7) ??
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Top Gene-Substance Interactions
GRB7 Interacts with These Diseases
| Disease | Score |
Substances That Increase GRB7
| Substances | Interaction | Organism | Category |
Substances That Decrease GRB7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Phosphatidylinositol Binding
- Protein Kinase Binding
- Rna Binding
- Sh3/Sh2 Adaptor Activity
- Identical Protein Binding
Biological Processes:
- Epidermal Growth Factor Receptor Signaling Pathway
- Erbb2 Signaling Pathway
- Leukocyte Migration
- Negative Regulation Of Translation
- Positive Regulation Of Cell Migration
- Stress Granule Assembly